CAS 3097026-24-6

Formel: C25H29ClN8O2

InChl: InChI=1S/C25H29ClN8O2/c1-3-33-12-14-34(15-13-33)25(36)30-18-10-8-17(9-11-18)29-24-28-16-20(26)22(32-24)31-21-7-5-4-6-19(21)23(35)27-2/h4-11,16H,3,12-15H2,1-2H3,(H,27,35)(H,30,36)(H2,28,29,31,32)

InChI Key: LBKYSWSHOQCXAH-UHFFFAOYSA-N

SMILES: CCN1CCN(CC1)C(=O)NC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4C(=O)NC)Cl

MY-1576

CAS: 3097026-24-6

MY-1576 is a FAK inhibitor with an IC₅₀ of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.

Formel: C₂₅H₂₉ClN₈O₂

Farbe und Form: Solid

Molekulargewicht: 509.01

Ref: TM-T205360