CAS 3099659-64-7

Formel: C21H22N4O3

InChl: InChI=1S/C21H22N4O3/c1-2-6-18-13-19(21(27)22-17-7-4-3-5-8-17)23-25(18)14-15-9-11-16(12-10-15)20(26)24-28/h3-5,7-13,28H,2,6,14H2,1H3,(H,22,27)(H,24,26)

InChI Key: JCPWBDUVBJFQSY-UHFFFAOYSA-N

SMILES: CCCC1=CC(=NN1CC2=CC=C(C=C2)C(=O)NO)C(=O)NC3=CC=CC=C3

HDAC6 degrader-5

CAS: 3099659-64-7

HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.

Formel: C₂₁H₂₂N₄O₃

Farbe und Form: Solid

Molekulargewicht: 378.424

Ref: TM-T204412