CAS 3104736-80-0

LUF7996

CAS: 3104736-80-0

LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.

Formel: C₃₉H₃₄Cl₂F₃N₅O₈S

Molekulargewicht: 860.68

Ref: TM-T215953