CAS 3105111-26-7

Formel: C25H30N6O2

InChl: InChI=1S/C25H30N6O2/c1-17(2)31-14-12-19(13-15-31)29-25-27-16-22(23(26)32)24(30-25)28-18-8-10-21(11-9-18)33-20-6-4-3-5-7-20/h3-11,16-17,19H,12-15H2,1-2H3,(H2,26,32)(H2,27,28,29,30)

InChI Key: UEXIGTLAFDRBTP-UHFFFAOYSA-N

SMILES: CC(C)N1CCC(CC1)NC2=NC=C(C(=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)C(=O)N

FLT3-IN-29

CAS: 3105111-26-7

FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0/G1 phase and effectively triggers apoptosis (Apoptosis). Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.

Formel: C₂₅H₃₀N₆O₂

Farbe und Form: Solid

Molekulargewicht: 446.545

Ref: TM-T204337