CAS 3111011-76-5

ALK-IN-35

CAS: 3111011-76-5

ALK-IN-35 is an ALK degrader with an IC50 of 0.74 nM. It inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes the formation of partially unfolded ALK conformations, and induces proteasome-mediated degradation of ALK. ALK-IN-35 effectively inhibits cancer cell proliferation and is applicable in research related to non-small-cell lung cancer.

Formel: C₃₆H₄₅ClN₇O₃P

Molekulargewicht: 690.21

Ref: TM-T218942