CAS 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamin

Beschreibung:

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamin (DOPE) ist ein Phospholipid, das häufig in der Biochemie und Molekularbiologie verwendet wird. Es ist durch seine dualen Oleoyl-Fettsäureketten gekennzeichnet, die zu seiner amphiphilen Natur beitragen und es ihm ermöglichen, in wässrigen Umgebungen Lipid-Doppelschichten und Vesikel zu bilden. Das Molekül besteht aus einem Glycerol-Rückgrat, zwei Oleoyl-Ketten und einer Phosphoethanolamin-Kopfgruppe, die ihm bei physiologischem pH einen netto neutralen Ladungszustand verleiht. DOPE ist bekannt für seine Fähigkeit, die Membranfusion zu erleichtern, und wird häufig in Arzneimittellieferungssystemen verwendet, insbesondere zur Einkapselung von Nukleinsäuren und Proteinen. Seine Fluidität und die Fähigkeit, verschiedene Konformationen anzunehmen, machen es zu einem wertvollen Bestandteil in liposomalen Formulierungen. Darüber hinaus kann DOPE die Stabilität und Wirksamkeit von Impfstoffen und Gentherapien verbessern. Die Substanz wird typischerweise unter kontrollierten Bedingungen gelagert, um ihre Integrität zu bewahren, und ist in organischen Lösungsmitteln löslich, was sie für verschiedene Laboranwendungen geeignet macht.

Formel: C₄₁H₇₈NO₈P

InChl: InChI=1/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

InChI Key: InChIKey=MWRBNPKJOOWZPW-NYVOMTAGSA-N

SMILES: [C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCN)(=O)O

Synonyme:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-[(9Z)-octadec-9-enoyloxy]propyl (9Z)-octadec-9-enoate
• 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphorylethanolamine
• 9-Octadecenoic acid (9Z)-, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 9-Octadecenoic acid (9Z)-, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• 9-Octadecenoic acid (Z)-, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• <span class="text-smallcaps">L</span>-α-Dioleoylphosphatidylethanolamine
• Coatsome MC 8181
• Coatsome ME 8181
• Dioleoyl phosphoethanolamine
• Dioleoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• Dioleoylphosphatidylethanolamine
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, <span class="text-smallcaps">L</span>-
• L-A-phosphatidylethanolamine dioleoyl
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, L-
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, L-
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, >99%
• (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-ETHA-N OLAMINE, 10 MG/ML
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)
• 1,2-Dioleoyl-sn-glycero-3-PE
• sn
• PE(18:1(9Z)/18:1(9Z))
• 18:1 PE
• 3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL
• O-(1-O,2-O-Dioleoyl-L-glycero-3-phospho)-2-aminoethanol
• 18:1 (Delta9-Cis) PE (DOPE)
• 2-Aminoethyl (R)-2,3-bis(oleoyloxy)propyl hydrogen phosphate
• 1,2-Dioleoyl-
• dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)
• 1,2-Dioleoyl-3-sn-phosphatidylethanolamine
• L-β,γ-Dioleoyl-α-cephalin
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9)
• DOPE
• L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN
• (+)-1-O,2-O-Dioleoyl-L-glycerol 3-(phosphoric acid 2-aminoethyl) ester
• Phosphoric acid hydrogen (2-aminoethyl)[(2R)-2,3-bis(oleoyloxy)propyl] ester
• L-A-PHOSPHATIDYLETHANOLAMINE, DIOLEO
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine≥ 98% (HPTLC)
• DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 98+%
• 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE
• COATSOME ME-8181 (DOPE)
• -glycero-3-phosphoethanolamine

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

Formel: C₄₁H₇₈NO₈P

Reinheit: >98.0%(T)

Farbe und Form: White to Light yellow powder to lump

Molekulargewicht: 744.05

Ref: 3B-D4251

9-Octadecenoic acid (9Z)-,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediylester

CAS: 4004-05-1

Formel: C₄₁H₇₈NO₈P

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 744.0337

Ref: IN-DA00IMFR

DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

Reinheit: ≥95%

Molekulargewicht: 744.03g/mol

Ref: 54-BUP17310

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

CAS: 4004-05-1

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

Formel: C₄₁H₇₈NO₈P

Reinheit: 98%

Molekulargewicht: 744.03g/mol

Ref: 54-BI12158

1,2-Dioleoyl-d62-sn-glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Formel: C41H16D62NO8P

Reinheit: >98%

Farbe und Form: Solid

Molekulargewicht: 806.43

Ref: 48-71-5718

1,2-Dioleoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Formel: C41H78NO8P

Reinheit: >98%

Farbe und Form: Solid

Molekulargewicht: 744.04

Ref: 48-37-1821

DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)

CAS: 4004-05-1

Formel: C₄₁H₇₈NO₈P

Molekulargewicht: 744.05

Ref: 4Z-F-106056

DOPE

CAS: 4004-05-1

DOPE, a neutral lipid, boosts cationic liposome efficiency in non-viral gene delivery.

Formel: C₄₁H₇₈NO₈P

Reinheit: 97.23% - ≥98%

Farbe und Form: Lyophilized Powder

Molekulargewicht: 744.03

Ref: TM-T19080

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

Formel: C₄₁H₇₈NO₈P

Reinheit: 98%

Farbe und Form: light yellow waxy solid

Molekulargewicht: 744.03368g/mol

Ref: 54-OR54392

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)

Kontrolliertes Produkt

CAS: 4004-05-1

Applications 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
References Misra, S.K., et al.: PLoS One, 8, e68305 (2013); MacDonald, R., et al.: J. Pharm. Sci., 88, 896 (1999); Chen, Y., et al.: Int. J. Nanomedicine, 8, 1573 (2013)

Formel: C₄₁H₇₈NO₈P

Farbe und Form: Neat

Molekulargewicht: 744.034

Ref: TR-D482210

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a synthetic lipid that has been extensively studied for its ability to form liposomes and other lipid bilayers. DOPE is used as a model system for studying the phase transition temperature of phospholipid membranes. DOPE has also been shown to be effective in the transfection of cells with plasmids and other DNA molecules. DOPE is cationic, which allows it to interact with anionic membrane proteins and facilitate their insertion into the membrane. This facilitates the formation of multilamellar vesicles, which are necessary for vesicle budding and fusion.

Formel: C₄₁H₇₈NO₈P

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 744.03 g/mol

Ref: 3D-FD148481

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

M01678 - 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Formel: C₄₁H₇₈NO₈P

Reinheit: 97%

Farbe und Form: Solid

Molekulargewicht: 744.048

Ref: 10-M01678

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4

Kontrolliertes Produkt

CAS: 4004-05-1

Formel: C₄₁D₄H₇₄NO₈P

Farbe und Form: Neat

Molekulargewicht: 748.058

Ref: TR-D482212