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CAS 475085-57-5

:

2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]essigsäure

Beschreibung:
Prostacyclin (PGI 2 ) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein- coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. 1 The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. 2 , 3 , 4 , 5 MRE- 269 is the active form of the prodrug NS- 304. It is a potent and selective agonist for the human IP receptor with a K i value of 20 nM. 6 In contrast to PGI 2 , which has a half- life of 30 seconds to a few minutes in vivo , plasma concentrations of MRE- 269 remain near peak levels for more than eight hours in rats and dogs. 6 Unlike the PGI 2 analogues, beraprost and iloprost, MRE- 269 lacks high affinity for the EP 3 receptor. 7 As a result, MRE- 269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reduced via EP 3 - mediated vasoconstriction. 7
Formel:C25H29N3O3
InChl:InChI=1S/C25H29N3O3/c1-19(2)28(15-9-10-16-31-18-23(29)30)22-17-26-24(20-11-5-3-6-12-20)25(27-22)21-13-7-4-8-14-21/h3-8,11-14,17,19H,9-10,15-16,18H2,1-2H3,(H,29,30)
InChI Key:InChIKey=OJQMKCBWYCWFPU-UHFFFAOYSA-N
SMILES:N(CCCCOCC(O)=O)(C(C)C)C=1N=C(C(=NC1)C2=CC=CC=C2)C3=CC=CC=C3
Synonyme:
  • Acetic acid, [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-
  • MRE 269
  • Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-
  • 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]acetic acid
  • ACT 333679
  • ACT-333679; MRE269; MRE 269; ACT333679; ACT 333679
  • Selexipag impurity 6/Selexipag Acid/2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid
  • {4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid
  • Selexipag internate 2
  • 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid
  • Weitere Synonyme anzeigen
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10 Produkte gefunden.