CAS 51798-45-9

Elastatinal

Beschreibung:

Elastatinal ist eine chemische Verbindung, die als zyklisches Peptid klassifiziert ist, speziell als Mitglied der Elastase-Inhibitoren. Es wird aus natürlichen Quellen gewonnen, insbesondere aus bestimmten Pilzarten. Die Verbindung zeigt eine bemerkenswerte biologische Aktivität, hauptsächlich als Inhibitor der Elastase, einem Enzym, das Elastin abbaut, einem Schlüsselprotein im Bindegewebe. Diese Hemmung kann Auswirkungen auf verschiedene physiologische Prozesse und potenzielle therapeutische Anwendungen haben, insbesondere bei Zuständen, die durch eine übermäßige Elastase-Aktivität gekennzeichnet sind, wie z.B. der chronisch obstruktiven Lungenerkrankung (COPD) und bestimmten entzündlichen Erkrankungen. Elastatinal zeichnet sich durch seine einzigartige zyklische Struktur aus, die zu seiner Stabilität und Spezifität bei der Bindung an Elastase beiträgt. Darüber hinaus wurde es aufgrund seiner Fähigkeit, die proteolytische Aktivität zu modulieren, für seine potenzielle Rolle in der Arzneimittelentwicklung untersucht. Wie bei vielen bioaktiven Verbindungen sind weitere Forschungen erforderlich, um seine Wirkmechanismen, Pharmakokinetik und potenzielle Nebenwirkungen in klinischen Umgebungen vollständig zu verstehen.

Formel: C₂₁H₃₆N₈O₇

InChl: InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI Key: InChIKey=IJWCGVPEDDQUDE-YGJAXBLXSA-N

SMILES: [C@H](C(N[C@H](C(N[C@H](C=O)C)=O)CCC(N)=O)=O)(NC(N[C@@H](CC(C)C)C(O)=O)=O)[C@]1(NC(N)=NCC1)[H]

Synonyme:

• (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-<span class="text-smallcaps">L</span>-glutamamide
• (2S,6S,9S,12S)-9-(3-amino-3-oxopropyl)-6-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• (2S,9S)-9-(3-amino-3-oxopropyl)-6-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• 9-(3-Amino-3-Oxopropyl)-6-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-12-Methyl-2-(2-Methylpropyl)-4,7,10,13-Tetraoxo-3,5,8,11-Tetraazatridecan-1-Oic Acid (Non-Preferred Name)
• <span class="text-smallcaps">L</smallcap>-Glutamamide, <smallcap>L</span>-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N¹-(1-methyl-2-oxoethyl)-, stereoisomer
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• Elastatinal
• N~2~-[(2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-2-({[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}amino)acetyl]-N~1~-[(2S)-1-oxopropan-2-yl]-L-glutamamide
• L-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-, stereoisomer

Elastatinal

CAS: 51798-45-9

Formel: C₂₁H₃₆N₈O₇

Reinheit: 85%

Molekulargewicht: 512.5599

Ref: IN-DA01E4MS

Elastatinal

CAS: 51798-45-9

Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.

Formel: C₂₁H₃₆N₈O₇

Farbe und Form: Yellowish Solid

Molekulargewicht: 512.56

Ref: TM-T20130

Elastatinal microbial

CAS: 51798-45-9

Formel: C₂₁H₃₆N₈O₇

Reinheit: ~0.64μg/ml (IC50, pH8.8, 37°C)

Farbe und Form: White to light-yellow or tan powder

Molekulargewicht: 512.60

Ref: 7W-GL1320

Elastatinal

CAS: 51798-45-9

Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and vaginal secretions. Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and

Formel: C₂₁H₃₆N₈O₇

Reinheit: Min. 95%

Molekulargewicht: 512.56 g/mol

Ref: 3D-IEL-4064

Elastatinal

Kontrolliertes Produkt

CAS: 51798-45-9

Applications Elastatinal is an elastase inhibitor.

Formel: C₂₁H₃₆N₈O₇

Farbe und Form: Neat

Molekulargewicht: 512.56

Ref: TR-E501008

Elastatinal

CAS: 51798-45-9

Elastatinal is a research tool that is used to activate cells by binding to a receptor on the cell surface. Elastatinal belongs to the Ligand class of compounds and has been shown to bind to various ion channels and receptors, including cell surface receptors. This ligand binds with high affinity to the α-adrenergic receptor (α-AR) and activates cells that express this receptor. It also inhibits the binding of other ligands, such as bradykinin, which may be useful in pharmacology. Elastatinal is an inhibitor of protein interactions, which can be used in Cell Biology studies.

Formel: C₂₁H₃₆N₈O₇

Reinheit: Min. 95%

Molekulargewicht: 512.56 g/mol

Ref: 3D-IEL-4064-V

Elastatinal

CAS: 51798-45-9

Irreversible elastase inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formel: C₂₁H₃₆N₈O₇

Molekulargewicht: 512.6

Ref: 02-J61120