CAS 6199-67-3

(+)-Cucurbitacin B

Formel: C₃₂H₄₆O₈

InChl: InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1

InChI Key: InChIKey=IXQKXEUSCPEQRD-DKRGWESNSA-N

SMILES: C[C@]12[C@@](C)([C@@]([C@@](C(/C=C/C(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C1)[H])CC(=O)[C@]3(C)[C@]2(CC=C4[C@]3(C[C@H](O)C(=O)C4(C)C)[H])[H]

Synonyme:

• (23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha,17xi,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2β,9β,10α,16α,23E)-25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
• 19-Nor-9β,10α-lanosta-5,23-diene-3,11,22-trione, 2β,16α,20,25-tetrahydroxy-9-methyl-, 25-acetate
• 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
• Amarine
• Cucurbitacine B
• Hy-N 0416
• NSC 144154
• NSC 49451

Cucurbitacin B

CAS: 6199-67-3

Formel: C₃₂H₄₆O₈

Reinheit: >98.0%(HPLC)

Farbe und Form: White to Light yellow powder to crystal

Molekulargewicht: 558.71

Ref: 3B-C3442

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formel: C₃₂H₄₆O₈

Reinheit: (HPLC) ≥95%

Farbe und Form: Powder

Molekulargewicht: 558.72

Ref: 11-2310S

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B

Formel: C₃₂H₄₆O₈

Reinheit: ≥95%

Molekulargewicht: 558.712

Ref: 54-BUP02619

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B (cucB) is a triterpenoid constituent of Cucurbitaceae vegetables and a promising phytochemical for cancer prevention, cucB induces G(2) arrest and apoptosis through a STAT3-independent but ROS-dependent mechanism in SW480 cells.

Formel: C₃₂H₄₆O₈

Reinheit: 95%~99%

Farbe und Form: White powder

Molekulargewicht: 558.712

Ref: BP-BP0414

Cucurbitacin B (Standard)

CAS: 6199-67-3

Cucurbitacin B (Standard) is a reference standard for research and analysis in studies involving Cucurbitacin B. Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

Formel: C₃₂H₄₆O₈

Farbe und Form: Solid

Molekulargewicht: 558.70

Ref: TM-TMSM-1841

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.

Formel: C₃₂H₄₆O₈

Reinheit: 97.1% - 99.93%

Farbe und Form: White Solid

Molekulargewicht: 558.70

Ref: TM-T3404

Cucurbitacin B

CAS: 6199-67-3

Formel: C₃₂H₄₆O₈

Reinheit: ≥ 98.0%

Farbe und Form: White to off-white powder

Molekulargewicht: 558.71

Ref: 7W-GY2441

Cucurbitacin B

CAS: 6199-67-3

Formel: C₃₂H₄₆O₈

Molekulargewicht: 558.71

Ref: 4Z-C-266004

Cucurbitacin B

CAS: 6199-67-3

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

Formel: C₃₂H₄₆O₈

Reinheit: 99%

Molekulargewicht: 558.7

Ref: IN-DG122458

Cucurbitacin B

CAS: 6199-67-3

Carboxylic acid with additional oxygen functions

Formel: C₃₂H₄₆O₈

Reinheit: ≥ 90.0 % (HPLC)

Farbe und Form: Powder

Molekulargewicht: 558.71

Ref: 5G-82226

Cucurbitacin B

Kontrolliertes Produkt

CAS: 6199-67-3

Cucurbitacin B is a triterpenoid compound, which is derived from plants primarily within the Cucurbitaceae family. This compound exhibits its mode of action through the inhibition of the JAK-STAT signaling pathway, effectively disrupting processes that are critical for cell survival and proliferation. As a result, Cucurbitacin B is being extensively studied for its antiproliferative and pro-apoptotic properties, especially in the context of cancer research.

Formel: C₃₂H₄₆O₈

Reinheit: Min. 95%

Farbe und Form: White Powder

Molekulargewicht: 558.7 g/mol

Ref: 3D-FC66008

Cucurbitacin B

CAS: 6199-67-3

Ref: BE-RMT12220

Cucurbitacin B

CAS: 6199-67-3

Ref: BE-RMCC392004

Cucurbitacin B

Kontrolliertes Produkt

CAS: 6199-67-3

Applications Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells.In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sun, Y., et al.: Eur. J. Pharmacol. 768, 28 (2015); Ren, G., et al.: J. Nat. Med. 69, 522 (2015); C&E News p. 10, Dec. 5, 2016j

Formel: C₃₂H₄₆O₈

Farbe und Form: Neat

Molekulargewicht: 558.7

Ref: TR-C833550