CAS 668980-17-4

Formel: C24H27Cl2N7O

InChl: InChI=1S/C24H27Cl2N7O/c25-17-7-6-16(19(26)14-17)15-29-22-18-4-3-9-28-21(18)30-24(31-22)33-12-10-32(11-13-33)23(34)20-5-1-2-8-27-20/h3-4,6-7,9,14,20,27H,1-2,5,8,10-13,15H2,(H,28,29,30,31)/t20-/m1/s1

InChI Key: GDQQUDANFRCFMF-HXUWFJFHSA-N

SMILES: C1CCN[C@H](C1)C(=O)N2CCN(CC2)C3=NC4=C(C=CC=N4)C(=N3)NCC5=C(C=C(C=C5)Cl)Cl

CCR4 antagonist 4

CAS: 668980-17-4

CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC₅₀ value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC₅₀ values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].

Formel: C₂₄H₂₇Cl₂N₇O

Farbe und Form: Solid

Molekulargewicht: 500.42

Ref: TM-T84701