CAS 9073-60-3

β-Lactamase

Beschreibung:

β-Lactamase ist ein Enzym, das eine entscheidende Rolle bei der Antibiotikaresistenz spielt, insbesondere gegen β-Lactam-Antibiotika wie Penicilline und Cephalosporine. Es wird von verschiedenen Bakterien produziert, einschließlich sowohl grampositiver als auch gramnegativer Arten. Die Hauptfunktion von β-Lactamase besteht darin, den β-Lactam-Ring dieser Antibiotika zu hydrolysieren, wodurch sie unwirksam werden und Bakterien in der Lage sind, in Anwesenheit dieser Medikamente zu überleben. Das Enzym weist eine Reihe von Eigenschaften auf, einschließlich seiner Fähigkeit, je nach Bakterienstamm und Art des β-Lactam-Antibiotikums in Spezifität und Aktivität zu variieren. β-Lactamases können in verschiedene Gruppen eingeteilt werden, basierend auf ihrer molekularen Struktur und ihrem Wirkmechanismus, einschließlich Serin-β-Lactamases und Metallo-β-Lactamases. Das Vorhandensein von β-Lactamase-Genen in bakteriellen Populationen ist ein bedeutendes Anliegen in klinischen Umgebungen, da es zum wachsenden Problem der Antibiotikaresistenz beiträgt, was die Behandlung von Infektionen erschwert. Das Verständnis der Mechanismen und Eigenschaften von β-Lactamases ist entscheidend für die Entwicklung neuer Strategien zur Bekämpfung von antibiotikaresistenten Infektionen.

Formel: Unspecified

Synonyme:

• 3: PN: WO2019216248 SEQID: 10 claimed DNA
• Carbapenamase
• Carbapenem hydrolase
• Carbapenem-hydrolyzing β-lactamase
• Carbapenemase
• Carbapenemase 1
• Cefinase
• Cefotaximase
• Ceftazidimase
• Ceftazimidase
• Cefuroximase
• Cephalosporinase
• Cephamycinase
• Cloxacilanase
• Difco Penase
• Difco Penase Concentrate
• E.C. 3.5.2.6
• E.C. 3.5.2.8
• Imipenem-hydrolyzing β-lactamase
• Imipenemase
• Lactamasa, Β-
• Lactamase
• Metallo-β-lactamase
• Metallo-β-lactamases
• Neutrapen
• Oxacillinase
• Oxyiminocephalosporinase
• Penase
• Penicilloyl serine transferase
• Proteins, gene blaZ
• β-Lactamase
• β-Lactamase II
• EC 3.5.2.6
• b-Lactamase, Bacillus cereus 569/H9
• CENTA B-LACTAMASE SUBSTRATE

Penicillinase (1mL will inactivate 120000 units of Penicillin) (contains 0.25% phenol as preservative substance)

CAS: 9001-74-5, 9073-60-3

Farbe und Form: Colorless clear liquid

Ref: 3B-P0310

Penicillinase (=Penicillin amido-β-lactamhydrolase), from Bacillus cereus, Lyophilized powder (2500000unit/vial)

CAS: 9001-74-5, 9073-60-3

Farbe und Form: White to Almost white powder to crystal

Ref: 3B-P0913

Penicillinase (=Penicillin amido-β-lactamhydrolase), from Bacillus cereus, Lyophilized powder (50000000unit/vial)

CAS: 9001-74-5, 9073-60-3

Farbe und Form: White to Almost white powder to crystal

Ref: 3B-P1259

β-Lactamase Kit 01

CAS: 9073-60-3

Beta-lactamase enzymes demonstrate activity against clinically relevant beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. This product may be of particular interest for laboratory teams who require the sterility testing of biological specimens or for environmental monitoring applications.

Ref: 3D-EBL_KIT01

LacBuster™-S bulk for plates (β-lactamase)

CAS: 9073-60-3

This product shows beta-lactamase activity against clinically relevant beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. This product may be of particular interest for laboratory teams who require the sterility testing of biological specimens or for environmental monitoring applications.

Ref: 3D-EBL039.5

SPM-1 (β-Lactamase)

CAS: 9073-60-3

SPM-1 (β-Lactamase) is an enzyme, which is a type of metallo-beta-lactamase enzyme, derived from bacterial origins, specifically from pathogens associated with nosocomial infections. This enzyme acts by hydrolyzing the amide bond in the beta-lactam ring of antibiotics, rendering β-lactam antibiotics ineffective. SPM-1 participates in antibiotic resistance by facilitating the degradation of a wide range of β-lactam antibiotics, including penicillins and cephalosporins, thereby nullifying their therapeutic effects.

Ref: 3D-EBL091.5

NMCA (β-Lactamase)

CAS: 9073-60-3

NMCA (β-Lactamase) is an enzyme that hydrolyzes β-lactam antibiotics, a type of product crucial for studies in antibiotic resistance mechanisms. This enzyme is derived from bacterial sources, specifically those strains known for their role in beta-lactam drug resistance. The mode of action of β-Lactamase involves the enzymatic breakdown of the β-lactam ring found in penicillins and cephalosporins, thereby neutralizing the antibiotic's efficacy. This catalytic process is an essential focus for researchers studying bacterial defense mechanisms and the development of resistant strains.

Ref: 3D-EBL096.6

KPC-1 (β-Lactamase)

CAS: 9073-60-3

KPC-1 (β-Lactamase) is an enzyme that breaks down β-lactam antibiotics, rendering them ineffective. It originates from strains of bacteria, particularly Klebsiella pneumoniae, which are significant sources of hospital-acquired infections. The mode of action involves hydrolyzing the β-lactam ring found in antibiotics such as penicillins and cephalosporins, neutralizing their antibacterial effects.

Ref: 3D-EBL095.5

VIM-15 (β-Lactamase)

CAS: 9073-60-3

VIM-15 (β-Lactamase) is a metallo-β-lactamase enzyme, which is derived from bacterial sources, particularly Gram-negative bacteria. Its mode of action involves the hydrolysis of β-lactam antibiotics, facilitating bacterial resistance. This enzyme employs zinc ions as cofactors to break the β-lactam ring, rendering these antibiotics ineffective against the bacteria that produce the enzyme. The hydrolysis process disrupts the antibiotic's structural integrity, crucial for its antibacterial activity, thereby nullifying its therapeutic effects.

Ref: 3D-EBL092.6

OXA-11 (β-Lactamase)

CAS: 9073-60-3

OXA-11 is a β-lactamase enzyme, which is a type of protein produced by certain bacteria. These enzymes are derived from the bacterial source and are responsible for antibiotic resistance. The primary mode of action of OXA-11 is the hydrolysis of the β-lactam ring found in various antibiotics, such as penicillins and cephalosporins, rendering them ineffective. This enzymatic activity allows bacteria to survive exposure to these antimicrobial agents, posing a significant challenge in clinical settings.

Ref: 3D-EBL094.6

SPM-1 (β-Lactamase)

CAS: 9073-60-3

SPM-1 (β-Lactamase) is a metallo-β-lactamase enzyme, which is derived from certain Gram-negative bacteria, such as Pseudomonas aeruginosa. This enzyme is characterized by its ability to hydrolyze a broad spectrum of β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems, due to the presence of a zinc ion in its active site. The zinc ion plays a crucial role in the catalytic mechanism by facilitating the cleavage of the β-lactam ring, rendering the antibiotic ineffective against bacterial cell wall synthesis.

Ref: 3D-EB10010

KPC-1 (β-Lactamase)

CAS: 9073-60-3

KPC-1 (β-Lactamase) is a specialized enzyme, which is produced by certain Gram-negative bacteria, notably Klebsiella pneumoniae. It functions by hydrolyzing the β-lactam ring found in a wide range of β-lactam antibiotics, such as penicillins and cephalosporins. This enzymatic action effectively neutralizes the antibiotic's antimicrobial properties, rendering the drugs ineffective against bacteria that produce KPC-1.

Ref: 3D-EB10014

NMCA (β-Lactamase)

CAS: 9073-60-3

NMCA (β-Lactamase) is an enzyme, specifically acclaimed for its role in conferring antibiotic resistance. It is derived from bacterial sources, where it naturally occurs as part of the bacterial defense mechanism against β-lactam antibiotics. NMCA (β-Lactamase) functions by hydrolyzing the β-lactam ring present in these antibiotics, effectively rendering them inactive. This mode of action disrupts the antibiotic's ability to inhibit cell wall synthesis within bacteria, thereby permitting bacterial survival and proliferation.

Farbe und Form: Powder

Ref: 3D-EB10015

VIM-15 (β-Lactamase)

CAS: 9073-60-3

VIM-15 (β-Lactamase) is an enzyme product, specifically a metallo-beta-lactamase, which is sourced from certain resistant bacterial strains. This enzyme functions by hydrolyzing the beta-lactam ring of antibiotics, rendering them ineffective. The primary mode of action involves the coordination of zinc ions at its active site, enabling the breakdown of a broad spectrum of beta-lactam antibiotics including penicillins, cephalosporins, and carbapenems. This enzymatic activity significantly contributes to antibiotic resistance, posing a challenge in the treatment of bacterial infections. Its prevalence is noted in healthcare settings, where multidrug-resistant organisms are a concern. VIM-15 is of particular interest in clinical microbiology research and antimicrobial resistance studies, where understanding its structure and function can aid in the development of new inhibitors, potentially restoring the efficacy of beta-lactam antibiotics against resistant strains. Its characterization and study are critical for developing strategies to combat antibiotic-resistant infections effectively.

Ref: 3D-EB10011

OXA-11 (β-Lactamase)

CAS: 9073-60-3

OXA-11 (β-Lactamase) is an enzyme of the β-lactamase class, which is primarily derived from Gram-negative bacteria. This enzyme is characterized by its ability to hydrolyze β-lactam antibiotics, rendering them ineffective by breaking the β-lactam ring, a crucial component of these antibiotics. OXA-11 is a notable member of the oxacillinase group within class D β-lactamases, known for its resistance to penicillins and cephalosporins.

Ref: 3D-EB10013

LacBuster™-L 500 (β-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL012.3

LacBuster™-L 250 (β-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL013.3

LacBuster™-L bulk (β-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL010.7

LacBuster™-S bulk (β-Lactamase)

CAS: 9073-60-3

This product shows beta-lactamase activity against clinically relevant beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. This product may be of particular interest for laboratory teams who require the sterility testing of biological specimens or for environmental monitoring applications.

Ref: 3D-EBL020.5

LacBuster™-L 1000 (β-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL011.3

LacBuster™-P bulk (β-lactamase)

CAS: 9073-60-3

Beta-lactamase enzyme targeting beta-lactam antibiotics

Ref: 3D-EBL040.5

LacBuster™ TSA broad range β-lactamase settle plates, 10 plates per pack, barcoded

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL065

LacBuster™ TSA broad range β-lactamase contact plates, 10 plates per pack, barcoded

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL066

LacBuster™ TSA broad range β-lactamase settle plates, 10 plates per pack, barcoded

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL063

LacBuster™ TSA broad range β-lactamase contact plates, 10 plates per pack, barcoded

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL064

LacBuster™-S 2000 (β-lactamase)

CAS: 9073-60-3

LacBuster™-S 2000 is an enzyme preparation, specifically a beta-lactamase, which is derived from bacterial sources known for their capacity to degrade beta-lactam antibiotics. Through hydrolytic cleavage of the beta-lactam ring, this enzyme neutralizes the efficacy of beta-lactam antibiotics, thereby rendering them inactive.

Ref: 3D-EBL023.2

LacBuster™-S 1000 (β-lactamase)

CAS: 9073-60-3

LacBuster™-S 1000 is an enzymatic product derived from microbial sources, specifically engineered for precision and efficiency. It is a beta-lactamase, which catalyzes the hydrolysis of the beta-lactam ring found in beta-lactam antibiotics such as penicillins and cephalosporins, rendering them inactive. The enzyme achieves this by breaking the amide bond within the beta-lactam ring, a critical structural component necessary for antibiotic activity.

Ref: 3D-EBL022.2

LacBuster™-S 5000 (β-lactamase)

CAS: 9073-60-3

LacBuster™-S 5000 is an enzymatic product, specifically a beta-lactamase, which originates from microbial sources known for their ability to produce enzymes that break down antibiotics. This product functions by hydrolyzing the beta-lactam ring of relevant antibiotics, thereby neutralizing their antibacterial activity.

Ref: 3D-EBL025.2

LacBuster™-S 50 (β-lactamase)

CAS: 9073-60-3

LacBuster™-S 50 is a beta-lactamase formulation, which is an enzyme of microbial origin with the ability to hydrolyze beta-lactam antibiotics. This enzymatic product is derived from specific bacterial species known for their resistance mechanisms, providing a robust capability to deactivate compounds such as penicillins and cephalosporins. Its mode of action involves the cleavage of the beta-lactam ring, a crucial structural component of these antibiotics, effectively neutralizing their antibacterial properties.

Ref: 3D-EBL021.2

LacBuster™-L concentrate

CAS: 9073-60-3

Beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL019.7

LacBuster™-L 100 (beta-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.beta lactamase I activity - min. 25.0 IU/mLbeta lactamase II activity - min. 10.0 IU/mL

Ref: 3D-EBL014.3

LacBuster™ (b-lactamase) settle plates

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL061

CENTA(TM) β-LACTAMASE SUBSTRATE

CAS: 9073-60-3

Formel: C₂₁H₁₇N₃O₈S₃

Farbe und Form: Solid

Molekulargewicht: 535.5700

Ref: IN-DA00GRR6

LacBuster™ (b-lactamase) contact plates

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL062