CAS 9073-60-3
:β-Lactamase
Beschreibung:
β-Lactamase ist ein Enzym, das eine entscheidende Rolle bei der Antibiotikaresistenz spielt, insbesondere gegen β-Lactam-Antibiotika wie Penicilline und Cephalosporine. Es wird von verschiedenen Bakterien produziert, einschließlich sowohl grampositiver als auch gramnegativer Arten. Die Hauptfunktion von β-Lactamase besteht darin, den β-Lactam-Ring dieser Antibiotika zu hydrolysieren, wodurch sie unwirksam werden und Bakterien in der Lage sind, in Anwesenheit dieser Medikamente zu überleben. Das Enzym weist eine Reihe von Eigenschaften auf, einschließlich seiner Fähigkeit, je nach Bakterienstamm und Art des β-Lactam-Antibiotikums in Spezifität und Aktivität zu variieren. β-Lactamases können in verschiedene Gruppen eingeteilt werden, basierend auf ihrer molekularen Struktur und ihrem Wirkmechanismus, einschließlich Serin-β-Lactamases und Metallo-β-Lactamases. Das Vorhandensein von β-Lactamase-Genen in bakteriellen Populationen ist ein bedeutendes Anliegen in klinischen Umgebungen, da es zum wachsenden Problem der Antibiotikaresistenz beiträgt, was die Behandlung von Infektionen erschwert. Das Verständnis der Mechanismen und Eigenschaften von β-Lactamases ist entscheidend für die Entwicklung neuer Strategien zur Bekämpfung von antibiotikaresistenten Infektionen.
Formel:Unspecified
Synonyme:- 3: PN: WO2019216248 SEQID: 10 claimed DNA
- Carbapenamase
- Carbapenem hydrolase
- Carbapenem-hydrolyzing β-lactamase
- Carbapenemase
- Carbapenemase 1
- Cefinase
- Cefotaximase
- Ceftazidimase
- Ceftazimidase
- Cefuroximase
- Cephalosporinase
- Cephamycinase
- Cloxacilanase
- Difco Penase
- Difco Penase Concentrate
- E.C. 3.5.2.6
- E.C. 3.5.2.8
- Imipenem-hydrolyzing β-lactamase
- Imipenemase
- Lactamasa, Β-
- Lactamase
- Metallo-β-lactamase
- Metallo-β-lactamases
- Neutrapen
- Oxacillinase
- Oxyiminocephalosporinase
- Penase
- Penicilloyl serine transferase
- Proteins, gene blaZ
- β-Lactamase
- β-Lactamase II
- EC 3.5.2.6
- b-Lactamase, Bacillus cereus 569/H9
- CENTA B-LACTAMASE SUBSTRATE
- Weitere Synonyme anzeigen
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Penicillinase (1mL will inactivate 120000 units of Penicillin) (contains 0.25% phenol as preservative substance)
CAS:Farbe und Form:Colorless clear liquidPenicillinase (=Penicillin amido-β-lactamhydrolase), from Bacillus cereus, Lyophilized powder (2500000unit/vial)
CAS:Farbe und Form:White to Almost white powder to crystalβ-LactaMase
CAS:β-LactaMase is a bacterially produced enzyme that hydrolyzes antibiotics such as penicillins, and its activity is inhibited by ethylenediaminetetraacetic acid (EDTA).Penicillinase (=Penicillin amido-β-lactamhydrolase), from Bacillus cereus, Lyophilized powder (50000000unit/vial)
CAS:Farbe und Form:White to Almost white powder to crystalLacBuster™-L 100 (beta-lactamase)
CAS:Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.beta lactamase I activity - min. 25.0 IU/mLbeta lactamase II activity - min. 10.0 IU/mLKPC-1 (β-Lactamase)
CAS:KPC-1 (β-Lactamase) is an enzyme that breaks down β-lactam antibiotics, rendering them ineffective. It originates from strains of bacteria, particularly Klebsiella pneumoniae, which are significant sources of hospital-acquired infections. The mode of action involves hydrolyzing the β-lactam ring found in antibiotics such as penicillins and cephalosporins, neutralizing their antibacterial effects.VIM-15 (β-Lactamase)
CAS:VIM-15 (β-Lactamase) is a metallo-β-lactamase enzyme, which is derived from bacterial sources, particularly Gram-negative bacteria. Its mode of action involves the hydrolysis of β-lactam antibiotics, facilitating bacterial resistance. This enzyme employs zinc ions as cofactors to break the β-lactam ring, rendering these antibiotics ineffective against the bacteria that produce the enzyme. The hydrolysis process disrupts the antibiotic's structural integrity, crucial for its antibacterial activity, thereby nullifying its therapeutic effects.OXA-11 (β-Lactamase)
CAS:OXA-11 is a β-lactamase enzyme, which is a type of protein produced by certain bacteria. These enzymes are derived from the bacterial source and are responsible for antibiotic resistance. The primary mode of action of OXA-11 is the hydrolysis of the β-lactam ring found in various antibiotics, such as penicillins and cephalosporins, rendering them ineffective. This enzymatic activity allows bacteria to survive exposure to these antimicrobial agents, posing a significant challenge in clinical settings.SPM-1 (β-Lactamase)
CAS:SPM-1 (β-Lactamase) is a metallo-β-lactamase enzyme, which is derived from certain Gram-negative bacteria, such as Pseudomonas aeruginosa. This enzyme is characterized by its ability to hydrolyze a broad spectrum of β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems, due to the presence of a zinc ion in its active site. The zinc ion plays a crucial role in the catalytic mechanism by facilitating the cleavage of the β-lactam ring, rendering the antibiotic ineffective against bacterial cell wall synthesis.KPC-1 (β-Lactamase)
CAS:KPC-1 (β-Lactamase) is a specialized enzyme, which is produced by certain Gram-negative bacteria, notably Klebsiella pneumoniae. It functions by hydrolyzing the β-lactam ring found in a wide range of β-lactam antibiotics, such as penicillins and cephalosporins. This enzymatic action effectively neutralizes the antibiotic's antimicrobial properties, rendering the drugs ineffective against bacteria that produce KPC-1.NMCA (β-Lactamase)
CAS:NMCA (β-Lactamase) is an enzyme, specifically acclaimed for its role in conferring antibiotic resistance. It is derived from bacterial sources, where it naturally occurs as part of the bacterial defense mechanism against β-lactam antibiotics. NMCA (β-Lactamase) functions by hydrolyzing the β-lactam ring present in these antibiotics, effectively rendering them inactive. This mode of action disrupts the antibiotic's ability to inhibit cell wall synthesis within bacteria, thereby permitting bacterial survival and proliferation.Farbe und Form:PowderLacBuster™-L 250 (β-lactamase)
CAS:Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.LacBuster™-L 500 (β-lactamase)
CAS:Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.
LacBuster™ TSA broad range β-lactamase settle plates, 10 plates per pack, barcoded
CAS:A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufactureLacBuster™ TSA broad range β-lactamase contact plates, 10 plates per pack, barcoded
CAS:A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufactureLacBuster™ TSA broad range β-lactamase settle plates, 10 plates per pack, barcoded
CAS:A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufactureLacBuster™ TSA broad range β-lactamase contact plates, 10 plates per pack, barcoded
CAS:A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufactureLacBuster™-S 1000 (β-lactamase)
CAS:LacBuster™-S 1000 is an enzymatic product derived from microbial sources, specifically engineered for precision and efficiency. It is a beta-lactamase, which catalyzes the hydrolysis of the beta-lactam ring found in beta-lactam antibiotics such as penicillins and cephalosporins, rendering them inactive. The enzyme achieves this by breaking the amide bond within the beta-lactam ring, a critical structural component necessary for antibiotic activity.LacBuster™-S 5000 (β-lactamase)
CAS:LacBuster™-S 5000 is an enzymatic product, specifically a beta-lactamase, which originates from microbial sources known for their ability to produce enzymes that break down antibiotics. This product functions by hydrolyzing the beta-lactam ring of relevant antibiotics, thereby neutralizing their antibacterial activity.
