CAS 9073-60-3

β-Lactamase

Beschreibung:

β-Lactamase ist ein Enzym, das eine entscheidende Rolle bei der Antibiotikaresistenz spielt, insbesondere gegen β-Lactam-Antibiotika wie Penicilline und Cephalosporine. Es wird von verschiedenen Bakterien produziert, einschließlich sowohl grampositiver als auch gramnegativer Arten. Die Hauptfunktion von β-Lactamase besteht darin, den β-Lactam-Ring dieser Antibiotika zu hydrolysieren, wodurch sie unwirksam werden und Bakterien in der Lage sind, in Anwesenheit dieser Medikamente zu überleben. Das Enzym weist eine Reihe von Eigenschaften auf, einschließlich seiner Fähigkeit, je nach Bakterienstamm und Art des β-Lactam-Antibiotikums in Spezifität und Aktivität zu variieren. β-Lactamases können in verschiedene Gruppen eingeteilt werden, basierend auf ihrer molekularen Struktur und ihrem Wirkmechanismus, einschließlich Serin-β-Lactamases und Metallo-β-Lactamases. Das Vorhandensein von β-Lactamase-Genen in bakteriellen Populationen ist ein bedeutendes Anliegen in klinischen Umgebungen, da es zum wachsenden Problem der Antibiotikaresistenz beiträgt, was die Behandlung von Infektionen erschwert. Das Verständnis der Mechanismen und Eigenschaften von β-Lactamases ist entscheidend für die Entwicklung neuer Strategien zur Bekämpfung von antibiotikaresistenten Infektionen.

Formel: Unspecified

Synonyme:

• 3: PN: WO2019216248 SEQID: 10 claimed DNA
• Carbapenamase
• Carbapenem hydrolase
• Carbapenem-hydrolyzing β-lactamase
• Carbapenemase
• Carbapenemase 1
• Cefinase
• Cefotaximase
• Ceftazidimase
• Ceftazimidase
• Cefuroximase
• Cephalosporinase
• Cephamycinase
• Cloxacilanase
• Difco Penase
• Difco Penase Concentrate
• E.C. 3.5.2.6
• E.C. 3.5.2.8
• Imipenem-hydrolyzing β-lactamase
• Imipenemase
• Lactamasa, Β-
• Lactamase
• Metallo-β-lactamase
• Metallo-β-lactamases
• Neutrapen
• Oxacillinase
• Oxyiminocephalosporinase
• Penase
• Penicilloyl serine transferase
• Proteins, gene blaZ
• β-Lactamase
• β-Lactamase II
• EC 3.5.2.6
• b-Lactamase, Bacillus cereus 569/H9
• CENTA B-LACTAMASE SUBSTRATE

LacBuster™-L concentrate

CAS: 9073-60-3

Beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL019.7

LacBuster™-L 100 (beta-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.beta lactamase I activity - min. 25.0 IU/mLbeta lactamase II activity - min. 10.0 IU/mL

Ref: 3D-EBL014.3

LacBuster™ (b-lactamase) settle plates

CAS: 9073-60-3

A general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. This product is suitable for the cultivation of a wide variety of microorganisms for environmental monitoring within the pharmaceutical industry and for high performance monitoring of your isolators and clean rooms during beta lactam manufacture

Ref: 3D-EBL061

LacBuster™-L 1000 (β-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL011.3

OXA-11 (β-Lactamase)

CAS: 9073-60-3

OXA-11 (β-Lactamase) is an enzyme of the β-lactamase class, which is primarily derived from Gram-negative bacteria. This enzyme is characterized by its ability to hydrolyze β-lactam antibiotics, rendering them ineffective by breaking the β-lactam ring, a crucial component of these antibiotics. OXA-11 is a notable member of the oxacillinase group within class D β-lactamases, known for its resistance to penicillins and cephalosporins.

Ref: 3D-EB10013

LacBuster™-L bulk (β-lactamase)

CAS: 9073-60-3

Ready to use beta-lactamase solution targeting beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. According to US Pharmacopeia (USP <71>) and EP, LacBusterTM-L is suitable for sterility testing methods such as membrane filtration and direct inoculation.

Ref: 3D-EBL010.7

LacBuster™-S bulk (β-Lactamase)

CAS: 9073-60-3

This product shows beta-lactamase activity against clinically relevant beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. This product may be of particular interest for laboratory teams who require the sterility testing of biological specimens or for environmental monitoring applications.

Ref: 3D-EBL020.5

LacBuster™-S bulk for plates (β-lactamase)

CAS: 9073-60-3

This product shows beta-lactamase activity against clinically relevant beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. This product may be of particular interest for laboratory teams who require the sterility testing of biological specimens or for environmental monitoring applications.

Ref: 3D-EBL039.5

SPM-1 (β-Lactamase)

CAS: 9073-60-3

SPM-1 (β-Lactamase) is an enzyme, which is a type of metallo-beta-lactamase enzyme, derived from bacterial origins, specifically from pathogens associated with nosocomial infections. This enzyme acts by hydrolyzing the amide bond in the beta-lactam ring of antibiotics, rendering β-lactam antibiotics ineffective. SPM-1 participates in antibiotic resistance by facilitating the degradation of a wide range of β-lactam antibiotics, including penicillins and cephalosporins, thereby nullifying their therapeutic effects.

Ref: 3D-EBL091.5

β-Lactamase Kit 01

CAS: 9073-60-3

Beta-lactamase enzymes demonstrate activity against clinically relevant beta-lactam antibiotics such as penicillins, carbapenems and cephalosporins. This product may be of particular interest for laboratory teams who require the sterility testing of biological specimens or for environmental monitoring applications.

Ref: 3D-EBL_KIT01