CAS 927887-18-1

Formel: C14H18ClIN4O2

InChl: InChI=1S/C14H17IN4O2.ClH/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16;/h4-7H,1-3H3,(H4,16,17,18,19);1H

InChI Key: QRBBKDZPXABQPE-UHFFFAOYSA-N

SMILES: CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC.Cl

AF-353 hydrochloride

CAS: 927887-18-1

This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC₅₀ of 8 in both human and rat, and a pIC₅₀ of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 µM) in cell lines that express human P2X3 and P2X2/3 receptors recombinantly. The compound also shows favorable pharmacokinetic properties, with a half-life (t1/2) of 1.63 hours and a time to reach maximum concentration (Tmax) of 30 minutes.

Formel: C₁₄H₁₇IN₄O₂HCl

Farbe und Form: Solid

Molekulargewicht: 436.68

Ref: TM-T85192

5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride

CAS: 927887-18-1

Formel: C₁₄H₁₈ClIN₄O₂

Molekulargewicht: 436.6758

Ref: IN-DA0035VC