NOS

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for …

Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations …

L-Arginine hydrochloride is a nitrogen donor for synthesis of nitric oxide.

Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor …

Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment …

Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a …

2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.

Flavone (2-Phenyl-4-chromone) have effects on CYP (P450) activity which are enzymes that metabolize most drugs …

Miconazole (R18134) is an imidazole antifungal agent that is used topically and by intravenous infusion.

Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid …

Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry …

Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has …

Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses …

GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide …

1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.

Schisandrone (Arisantetralone C) is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.

Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of …

Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a …

Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated …

Dunnianol shows anti-inflammatory activity and moderate antibacterial activity.

Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and …

Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.

Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, …

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it …

Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in …

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite …

EIT hydrobromide (S-Ethylisothiourea hydrobromide) is an iNOS inhibitor.

EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic …

Carboxyebselen (HOOC-Ebs) is an endothelial nitric oxide synthase (eNOS) inhibitor that is potent and selective.

Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose …

Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 …

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on …

5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may …

Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the …

Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic …

iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase …

Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in …

Nyasol may have potential to be developed as medicines for the treatment of allergies by …

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also …

Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide …

Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both …

Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly …

Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) …

Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. …

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it …

Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM.

NOS1-IN-1(nNOS Inhibitor I) is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 …

Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be …

Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food …

Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as …

Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.

Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.

Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic …

Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) can inhibit xanthine oxidase (xanthine oxidase; XO) activity, lipid peroxidation and …

β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 …

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS …

Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and …

1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an …

Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced …

Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and …

Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes …

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in …

Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing …

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity …

Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it …

Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and …

Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin …

Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then …

Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm …

1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can …