MAPK
MAPKs sind eine Familie von Proteinkinasen, die an einer Vielzahl zellulärer Prozesse beteiligt sind, einschließlich Wachstum, Proliferation, Differenzierung und Stressreaktionen. Der MAPK-Signalweg besteht aus mehreren Ebenen, einschließlich ERK, JNK und p38 MAPKs, die jeweils unterschiedliche Rollen in der Zellfunktion spielen. Eine Fehlregulation der MAPK-Signalübertragung ist mit Krebs, entzündlichen Erkrankungen und Stoffwechselstörungen verbunden. Bei CymitQuimica bieten wir eine breite Palette von MAPK-Inhibitoren und -Aktivatoren zur Unterstützung Ihrer Forschung in Zellbiologie, Signaltransduktion und Krankheitsmechanismen an.
901 Produkte aus dem Bereich "MAPK" gefunden
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INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Formel:C22H24N4OSReinheit:99.95%Farbe und Form:SolidMolekulargewicht:392.52Ref: TM-T11657
2mg34,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg82,00€25mg136,00€50mg203,00€100mg299,00€200mg416,00€(R)-Ketorolac
CAS:(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.Formel:C15H13NO3Reinheit:99.55%Farbe und Form:SolidMolekulargewicht:255.27Ref: TM-T12624
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg222,00€50mg313,00€100mg437,00€MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formel:C33H39N7O2Reinheit:97.3% - 99.07%Farbe und Form:SolidMolekulargewicht:565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€1mL*10mM (DMSO)166,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formel:C23H25F3N4O3Reinheit:99.2% - 99.66%Farbe und Form:SolidMolekulargewicht:462.46Ref: TM-T12979
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg439,00€50mg628,00€100mg872,00€500mg1.738,00€ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Formel:C50H62N14O6S2Reinheit:99.24%Farbe und Form:SolidMolekulargewicht:1019.25Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formel:C21H23F3N6O2Reinheit:98.66% - 99.28%Farbe und Form:SolidMolekulargewicht:448.44SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formel:C5H3N5O2S3Reinheit:98.39%Farbe und Form:SolidMolekulargewicht:261.3KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Formel:C25H19ClF2N4O3SReinheit:97.46%Farbe und Form:SolidMolekulargewicht:528.96(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Formel:C31H28N6O2Reinheit:97.80%Farbe und Form:SoildMolekulargewicht:516.59K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formel:C31H33ClN4O4Reinheit:99.00%Farbe und Form:SolidMolekulargewicht:561.07Ref: TM-T11738
1mg71,00€5mg161,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Formel:C15H12ClN5Reinheit:98.07%Farbe und Form:SolidMolekulargewicht:297.74Ref: TM-T11942
5mg44,00€1mL*10mM (DMSO)48,00€10mg74,00€25mg144,00€50mg222,00€100mg354,00€200mg523,00€500mg797,00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Formel:C21H18N4OSReinheit:98.13%Farbe und Form:SolidMolekulargewicht:374.46Ref: TM-T16501
1mg34,00€5mg105,00€1mL*10mM (DMSO)177,00€10mg192,00€25mg394,00€50mg587,00€100mg788,00€500mg1.575,00€BAY 2965501
CAS:BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Formel:C20H19FN4O3SReinheit:99.89%Farbe und Form:SolidMolekulargewicht:414.45ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Formel:C25H20N4O2Reinheit:99.72% - 99.79%Farbe und Form:SolidMolekulargewicht:408.45Ref: TM-T15250
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg140,00€50mg215,00€100mg318,00€500mg692,00€MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Formel:C22H24N6OReinheit:99.69%Farbe und Form:SolidMolekulargewicht:388.47MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formel:C21H18N4O2Reinheit:99.58%Farbe und Form:SolidMolekulargewicht:358.39Ref: TM-T12058
1mg34,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg87,00€25mg172,00€50mg250,00€100mg350,00€200mg480,00€CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formel:C22H21F3N6O2Reinheit:99.42%Farbe und Form:SolidMolekulargewicht:458.44Divarasib
CAS:Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.Formel:C29H32ClF4N7O2Reinheit:99.23% - 99.83%Farbe und Form:SolidMolekulargewicht:622.06Ref: TM-T9972
1mg220,00€5mg522,00€1mL*10mM (DMSO)707,00€10mg737,00€25mg1.161,00€50mg1.603,00€100mg2.133,00€LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formel:C27H19F3N8OReinheit:99.03%Farbe und Form:SolidMolekulargewicht:528.49Azelnidipine
CAS:Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Formel:C33H34N4O6Reinheit:99.78%Farbe und Form:Light Yellowish PowderMolekulargewicht:582.65Ref: TM-T0121
2mg34,00€5mg49,00€1mL*10mM (DMSO)59,00€10mg64,00€25mg103,00€50mg167,00€100mg260,00€200mg385,00€
