Gamma-Sekretase

Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity …

Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with …

ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch …

CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.

BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).

gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies …

ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor …

Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used …

Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. …

BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for …

RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively …

CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 …

Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 …

γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and …

Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that …

Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser …

Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ …

RO7185876 is a selective gamma secretase modulator, which can be used in the study of …

Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces …

BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch …

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide …

FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).

PE859 is a potent inhibitor of both tau and Aβ aggregation.

Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive …

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β …

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of …

Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important …

Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch …

LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase …

1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant …

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting …

JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling

Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, …

MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.

1. Bruceine D from Brucea javanica, may have the potential to be used as a …

JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) …

CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM …

BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.