Fidaxomicin

CAS: 873857-62-6

Ref. 3D-AF31015

Produktinformation

• Name: Fidaxomicin
• Synonyme: Clostomicin B1LipiarmycinR-Tiacumicin B, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one, Clostomicin B₁, Dificid, Dificlir, Fidaxomycin, Lipiarmicin, Lipiarmycin, Lipiarmycin A 3, Opt-80, Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-, Par 01, Par-101, R-Tiacumicin B, Tiacumicin B

Beschreibung

Fidaxomicin is a broad-spectrum antibiotic that is similar to vancomycin and inhibits bacterial growth by binding to the bacterial ribosome. It has been shown to be effective in patients with hepatic impairment and for the treatment of infectious diseases caused by bacteria that are resistant to other antibiotics. Fidaxomicin binds to the active site of the bacterial ribosome, preventing peptide bond formation and inhibiting protein synthesis. Fidaxomicin can also bind to mammalian ribosomes and interfere with protein synthesis in cells, which may lead to toxic effects on the liver. This drug interacts with drugs that inhibit cytochrome P450 enzymes (e.g., erythromycin) or drugs that are substrates for this enzyme (e.g., cyclosporine). Fidaxomicin is excreted unchanged in human urine and has a half-life of approximately 2 hours in plasma.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,058.04 g/mol
• Formel: C₅₂H₇₄Cl₂O₁₈
• Reinheit: Min. 98 Area-%
• Farbe/Form: White Powder