Org-26576

CAS: 1026791-61-6

Ref. 3D-BRB79161

Produktinformation

• Name: Org-26576
• CAS: 1026791-61-6

Beschreibung

Org-26576 is a potent and selective antagonist of the neurotrophic receptor TrkB. It binds to the extracellular domain of human TrkB, blocking the interaction with its ligands, including brain-derived neurotrophic factor and basic fibroblast growth factor. Org-26576 has shown antidepressant effects in animal models of depression, but this effect is dose-dependent. The compound also inhibits glutamate neurotransmission by competitively blocking N-methyl D-aspartate receptors. Org-26576 has been shown to be safe for use in animals and humans, with no serious adverse events reported so far. Pharmacokinetic studies show that Org-26576 crosses the blood brain barrier and is rapidly absorbed after oral administration.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 204.23 g/mol
• Formel: C₁₁H₁₂N₂O₂
• Reinheit: Min. 95%