CAS 1026791-61-6

Formel: C11H12N2O2

InChl: InChI=1S/C11H12N2O2/c14-11-9-4-1-5-12-10(9)15-7-8-3-2-6-13(8)11/h1,4-5,8H,2-3,6-7H2/t8-/m0/s1

InChI Key: FIKUEZUFASUKAH-QMMMGPOBSA-N

SMILES: C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1

Org-26576

CAS: 1026791-61-6

Org-26576

Formel: C₁₁H₁₂N₂O₂

Reinheit: ≥98%

Molekulargewicht: 204.23

Ref: 54-BUP10143

Org-26576

CAS: 1026791-61-6

Org-26576 is a positive allosteric modulator of the AMPA receptor.

Formel: C₁₁H₁₂N₂O₂

Reinheit: 99.67%

Farbe und Form: White Solid

Molekulargewicht: 204.23

Ref: TM-T16402

Org-26576

CAS: 1026791-61-6

Ref: IN-DA01EOC2

Org-26576

CAS: 1026791-61-6

Org-26576 is a potent and selective antagonist of the neurotrophic receptor TrkB. It binds to the extracellular domain of human TrkB, blocking the interaction with its ligands, including brain-derived neurotrophic factor and basic fibroblast growth factor. Org-26576 has shown antidepressant effects in animal models of depression, but this effect is dose-dependent. The compound also inhibits glutamate neurotransmission by competitively blocking N-methyl D-aspartate receptors. Org-26576 has been shown to be safe for use in animals and humans, with no serious adverse events reported so far. Pharmacokinetic studies show that Org-26576 crosses the blood brain barrier and is rapidly absorbed after oral administration.

Formel: C₁₁H₁₂N₂O₂

Reinheit: Min. 95%

Molekulargewicht: 204.23 g/mol

Ref: 3D-BRB79161