RET V804M-IN-1

CAS: 2414909-94-5

Ref. 3D-EP176311

Produktinformation

• Name: RET V804M-IN-1
• Synonyme: 4-[5-(3-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide

Beschreibung

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 344.37 g/mol
• Formel: C₁₉H₁₆N₆O
• Reinheit: Min. 97 Area-%
• Farbe/Form: White Powder
• InChl: InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)
• InChI Key: InChIKey=LMGXQBQAUALFTB-UHFFFAOYSA-N
• SMILES: NC(=O)c1ccc(-c2cnn3ccc(NCc4cccnc4)nc23)cc1