3'-O-Methylguanosine

CAS: 10300-27-3

Ref. 3D-NM06232

Produktinformation

• Name: 3'-O-Methylguanosine
• Synonyme: 2-Amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one, 3-Omg, Nsc 106541, Guanosine, 3'-O-methyl-, 2-amino-9-(3-O-methylpentofuranosyl)-3,9-dihydro-6H-purin-6-one, 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-3H-purin-6-one

Beschreibung

3'-O-Methylguanosine is a nucleoside that is found in the guanine molecule and has been shown to have inhibitory properties against malignant brain tumors. 3'-O-Methylguanosine blocks the synthesis of DNA, RNA, and peptide hormones. It also inhibits the growth of erythromycin-resistant strains of bacteria. The kinetic data for 3'-O-Methylguanosine was obtained from experiments with leukemic mice and carcinoma cell lines. The enzyme glut1 regulates the rate of metabolism of 3'-O-Methylguanosine. It is metabolized by dehydroascorbic acid reductase to 3'-deoxyadenosine monophosphate (dAMP) and then to adenosine monophosphate (AMP). The optimum pH for this reaction is 7.3 at 37 degrees Celsius.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 297.27 g/mol
• Formel: C₁₁H₁₅N₅O₅
• Reinheit: Min. 98 Area-%
• Farbe/Form: White Off-White Powder