[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4

CAS: 284462-37-9

Ref. TR-A618944

Produktinformation

• Name: [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4
• Synonyme: 4-(4-amino-2,3,5,6-tetradeuteriophenoxy)-N-methylpyridine-2-carboxamide, 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-, 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide, 4-(4-Aminophenoxy)-N-methylpicolin Amide, 4-(4-Aminophenoxy)pyridine-2-carboxylic acid methylamide, 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide, 4-[2-(N-Methylcarbamyl)-4-pyridyloxy]aniline, 4-[[2-(Methylcarbamoyl)pyridin-4-yl]oxy]aniline, 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline, 4-[[2-(N-Methylcarbamoyl)pyridin-4-yl]oxy]aniline, N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide, [4-(4-Aminophenoxy)(2-Pyridyl)]-N-Methylcarboxamide

Beschreibung

Applications [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4 is an intermediate in the synthesis of Sorafenib-d4 (S676853); a labelled version of Sorafenib (S676850), a potent RAF kinase inhibitor.
References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003);Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004);Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004);Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 247.286
• Formel: C₁₃D₄H₉N₃O₂
• Farbe/Form: Neat
• InChl: InChI=1S/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)/i2D,3D,4D,5D
• InChI Key: InChIKey=RXZZBPYPZLAEFC-QFFDRWTDSA-N
• SMILES: [2H]c1c([2H])c(Oc2ccnc(C(=O)NC)c2)c([2H])c([2H])c1N