Withanolide A

CAS: 32911-62-9

Ref. TR-W498950

Produktinformation

• Name: Withanolide A
• Synonyme: (5α,6α,7α,22R)-6,7-epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic Acid δ-Lactone, (22R)-6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-5α-Ergosta-2,24-dien-26-oic Acid δ-Lactone, 6,7-Epoxy-1H-cyclopenta[a]phenanthrene Ergosta-2,24-dien-26-oic Acid Deriv., 5,20α-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide, 5α,20αF(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide, Withaniol, 5,20a-Dihydroxy-6a,7a-epoxy-1-oxowitha-2,24-dienolide, 5a,20aF(R)-Dihydroxy-6a,7a-epoxy-1-oxowitha-2,24-dienolide, 5a-Ergosta-2,24-dien-26-oic acid, 6a,7a-epoxy-5,20,22-trihydroxy-1-oxo-, d-lactone, (22R)- (8CI), 5α,20α_F(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide, 5α-Ergosta-2,24-dien-26-oic acid, 6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-, δ-lactone, (22R)-, 6,7-Epoxy-1H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv., Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,20,22-trihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-

Beschreibung

Applications Withanolide A, is a neuritogenic steroid. It may act as deterrent for feeding insect larva and other herbivores. Withaferin A, causes activation of Notch2 and Notch4 in human breast cancer cells, and thus used as novel anticancer agents.
References Liffert, R., et al.: Chemical Science, 4, 2851 (2013); Lee. J., et al.: Breast Cancer, Res. treat., 136, 45 (2012);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 470.60
• Formel: C₂₈H₃₈O₆
• Farbe/Form: Neat
• InChl: InChI=1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1
• InChI Key: InChIKey=DXWHOKCXBGLTMQ-SFQAJKIESA-N
• SMILES: CC1=C(C)C(=O)O[C@@H]([C@](C)(O)[C@H]2CC[C@H]3[C@@H]4[C@@H]5O[C@@H]5[C@@]5(O)CC=CC(=O)[C@]5(C)[C@H]4CC[C@@]32C)C1