CAS 1038549-25-5

Fórmula: C25H25N5O3

InChI: InChI=1S/C25H25N5O3/c26-23(31)18-5-7-21(8-6-18)30-25(33)28-14-16-2-1-3-19(12-16)24(32)29-22-9-4-17-10-11-27-15-20(17)13-22/h1-9,12-13,27H,10-11,14-15H2,(H2,26,31)(H,29,32)(H2,28,30,33)

Clave InChI: SCIFUGGHOXNSJC-UHFFFAOYSA-N

SMILES: C1CNCC2=C1C=CC(=C2)NC(=O)C3=CC=CC(=C3)CNC(=O)NC4=CC=C(C=C4)C(=O)N

ROCK-IN-10

CAS: 1038549-25-5

ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].

Fórmula: C₂₅H₂₅N₅O₃

Forma y color: Solid

Peso molecular: 443.507

Ref: TM-T84502