CAS 104987-11-3

Tacrolimus

Descripción:

Tacrolimus, con el número CAS 104987-11-3, es un fármaco inmunosupresor utilizado principalmente para prevenir el rechazo de órganos en pacientes trasplantados y para tratar ciertas condiciones autoinmunitarias. Es una lactona macrólida derivada de la bacteria Streptomyces tsukubaensis. Tacrolimus funciona inhibiendo la activación y proliferación de linfocitos T, principalmente a través de la inhibición de la calcineurina, una enzima crítica en la señalización de células T. Este mecanismo ayuda a suprimir la respuesta inmune. La sustancia se administra típicamente en su forma tópica para condiciones de la piel como la dermatitis atópica o como una formulación oral para uso sistémico. Tacrolimus es lipofílico, lo que influye en su absorción y distribución en el cuerpo. Tiene una vida media relativamente larga, lo que requiere un monitoreo cuidadoso de los niveles en sangre para evitar toxicidad. Los efectos secundarios comunes incluyen un mayor riesgo de infecciones, nefrotoxicidad y neurotoxicidad. Debido a sus potentes efectos inmunosupresores, Tacrolimus a menudo se utiliza en conjunto con otros inmunosupresores para mejorar la eficacia mientras se minimizan los efectos adversos.

Fórmula: C₄₄H₆₉NO₁₂

InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

Clave InChI: InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H]

Sinónimos:

• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• FR 900506
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

Tacrolimus Monohydrate

CAS: 104987-11-3, 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: >80.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 822.05

Ref: 3B-M2258

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 804.0182

Ref: IN-DA0039L0

FK-506

CAS: 104987-11-3

FK-506

Fórmula: C₄₄H₆₉NO₁₂

Pureza: By hplc: 99.91% (Typical Value in Batch COA)

Forma y color: white powder

Peso molecular: 804.01816g/mol

Ref: 54-BIF1003

Tacrolimus

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Forma y color: White To Off-White Solid

Peso molecular: 804.03

Ref: 4Z-T-391

Tacrolimus

CAS: 104987-11-3

Tacrolimus

Pureza: ≥98%

Peso molecular: 804.02g/mol

Ref: 54-BUP15701

Tacrolimus

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Pureza: 95%~99%

Peso molecular: 804.031

Ref: BP-BP1358

Tacrolimus

CAS: 104987-11-3

Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein

Fórmula: C₄₄H₆₉NO₁₂

Pureza: 98% - 99.94%

Forma y color: White Or Off-White Crystalline Powder

Peso molecular: 804.02

Ref: TM-T2144

Tacrolimus (FK506)

CAS: 104987-11-3

Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)

Fórmula: C₄₄H₆₉NO₁₂

Forma y color: Neat

Peso molecular: 804.02

Ref: TR-F370000

Tacrolimus

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Peso molecular: 804.03

Ref: ST-EA-CP-T39000

Tacrolimus

CAS: 104987-11-3

Antirheumatic; immunosuppressant; neuroprotective; neuroregenerative

Fórmula: C₄₄H₆₉NO₁₂

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 804.02 g/mol

Ref: 3D-AT23293

Tacrolimus - Bio-X ™

CAS: 104987-11-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.

Fórmula: C₄₄H₆₉NO₁₂

Pureza: Min. 95%

Forma y color: White Off-White Powder

Peso molecular: 804.02 g/mol

Ref: 3D-BT164430

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Producto controlado

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Fórmula: MixtureVisitourWebsite

Forma y color: Mixture

Peso molecular: Mixture - Visit our Website

Ref: TR-E608165

FK-506 (Tacrolimus)

CAS: 104987-11-3

FK-506 is an immunosuppressant that is produced by fermentation. It is used to prevent the rejection of transplanted organs and to treat a number of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. FK-506 binds to the IL-2 receptor on T-cells and inhibits their proliferation, thereby preventing activation of other immune cells. FK-506 has been shown to be effective in treating a number of diseases, including myocardial infarcts, coronary heart disease, and oral hypoglycaemic. The optimum concentration for this drug is not known, but it appears that higher concentrations are more beneficial in treating some conditions.

Fórmula: C₄₄H₆₉NO₁₂

Pureza: Min. 95%

Peso molecular: 804 g/mol

Ref: 3D-INT-3098-PI