CAS 59865-13-3

Ciclosporina A

Descripción:

Ciclosporina A es un polipéptido cíclico compuesto por 11 aminoácidos, conocido principalmente por sus propiedades inmunosupresoras. Es producido por el hongo Tolypocladium inflatum y se utiliza ampliamente en entornos clínicos, particularmente en trasplantes de órganos y enfermedades autoinmunes, para prevenir el rechazo de órganos y manejar condiciones como la artritis reumatoide. La sustancia funciona inhibiendo la activación de los linfocitos T, reduciendo así la respuesta inmune. Ciclosporina A es lipofílico, lo que afecta su absorción y distribución en el cuerpo; generalmente se administra por vía oral o intravenosa. Su farmacocinética puede verse influenciada por varios factores, incluyendo la ingesta de alimentos y medicamentos concurrentes, lo que requiere un monitoreo cuidadoso de los niveles en sangre para evitar toxicidad. Los efectos adversos pueden incluir nefrotoxicidad, hipertensión y mayor susceptibilidad a infecciones. Debido a sus interacciones complejas y efectos secundarios, Ciclosporina A requiere una gestión cuidadosa y ajustes de dosis basados en la respuesta individual del paciente y el contexto clínico.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Clave InChI: PMATZTZNYRCHOR-CGLBZJNRSA-N

SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Sinónimos:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: >97.0%(HPLC)(N)

Forma y color: White to Almost white powder to crystal

Peso molecular: 1,202.64

Ref: 3B-C2408

Cyclosporin A, 99+%

CAS: 59865-13-3

Cyclosporin A, 59865-13-3, or cyclosporine, is a cyclic polypeptide which acts as a calcineurin inhibitor and immunosuppressive agent. Learn more at Thermo Fisher Scientific.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99+%

Forma y color: White, Powder or crystals or crystalline powder

Peso molecular: 1202.61

Ref: 02-J63191

CICLOSPORIN CRS

CAS: 59865-13-3

CICLOSPORIN CRS

Forma y color: Added

Ref: 41-C2163000

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

CAS: 59865-13-3

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

Forma y color: Added

Ref: 41-Y0002292

Cyclosporine

CAS: 59865-13-3

Lactams, nesoi

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Forma y color: White Powder

Peso molecular: 1201.84137

Ref: 45-1158504

Cyclosporine A from Beauveria Nivea

CAS: 59865-13-3

Cyclosporine A from Beauveria Nivea

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99%

Forma y color: White Solid

Peso molecular: 1202.61124

Ref: 54-BITP1533

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99.00% - 99.94%

Forma y color: White Solid

Peso molecular: 1202.61

Ref: TM-T0945

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: ≥98%

Peso molecular: 1202.61

Ref: 54-BUP14762

Cyclosporin A, USP grade

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: ≤ 0.7%

Forma y color: Colourless crystals, or white to almost white powder

Peso molecular: 1202.61

Ref: 7W-GA2331

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 97%

Forma y color: Solid-Powder

Peso molecular: 1202.62

Ref: 54-BI4559

Cyclosporin A-13C2-d4 (Cyclosporine-13C2-d4)

CAS: 59865-13-3

Fórmula: C₆₀₁₃C₂H₁₀₇D₄N₁₁O₁₂

Peso molecular: 1208.64

Ref: 4Z-PC-5441

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 98.5 - 101.5 % (dried basis)

Forma y color: Colourless crystals, or white to almost white powder

Peso molecular: 1202.61

Ref: 7W-GA6323

Cyclosporin A (Cyclosporine)

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Forma y color: White To Off-White Solid

Peso molecular: 1202.64

Ref: 4Z-PC-541

Cyclosporin A

Producto controlado

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1202.61

Ref: 04-C11836300

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 95%~99%

Peso molecular: 1202.64

Ref: BP-BP0438

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 1202.6112

Ref: IN-DA00IKI7

Ciclosporin

Producto controlado

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1202.61

Ref: 86-MM0241.00

Cyclosporin A-d4 (Major)

Producto controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₀₇D₄N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Producto controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1202.61

Ref: TR-C988900