CAS 1069-79-0

1,2-Distearoil-sn-glicero-3-fosfoetanolamina

Descripción:

1,2-Distearoil-sn-glicero-3-fosfoetanolamina (DSPE) es un fosfolípido comúnmente utilizado en aplicaciones de bioquímica y farmacéuticas. Presenta dos cadenas de ácido esteárico, que contribuyen a sus propiedades hidrofóbicas, y un grupo cabeza de fosfoetanolamina que le confiere hidrofobicidad. Esta naturaleza anfifílica permite que el DSPE forme bicapas lipídicas y micelas, lo que lo hace valioso en sistemas de liberación de fármacos, particularmente para encapsular fármacos hidrofóbicos. El DSPE es conocido por su estabilidad y capacidad para formar liposomas, que son vesículas esféricas que pueden encapsular diversas sustancias. El compuesto se utiliza a menudo en la formulación de fármacos y vacunas liposomales, mejorando la biodisponibilidad y el objetivo de los agentes terapéuticos. Además, el DSPE puede ser modificado para incluir cadenas de polietilenglicol (PEG), mejorando el tiempo de circulación y reduciendo la inmunogenicidad. Su biocompatibilidad y versatilidad lo convierten en un componente crucial en el desarrollo de nanotransportadores para la liberación dirigida de fármacos y aplicaciones de terapia génica.

Fórmula: C₄₁H₈₂NO₈P

InChI: InChI=1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)/t39-/m1/s1

Clave InChI: InChIKey=LVNGJLRDBYCPGB-LDLOPFEMSA-N

SMILES: [C@@H](OC(CCCCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O

Sinónimos:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(octadecanoyloxy)propyl octadecanoate
• (R)-Distearoylphosphatidylethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
• 3-{[(2-Aminoethoxy)(Hydroxy)Phosphoryl]Oxy}-2-(Octadecanoyloxy)Propyl Octadecanoate
• 64: PN: WO2017201317 SEQID: 137 claimed RNA
• <span class="text-smallcaps">L</span>-α-Distearoylphosphatidylethanolamine
• <span class="text-smallcaps">L</span>-β,γ-Distearoyl-α-phosphatidylethanolamine
• Coatsome ME 8080
• Distearoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• L-A-phosphatidylethanolamine,distearoyl
• Octadecanoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• Octadecanoic acid, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• Octadecanoic acid, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• Stearin, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• L-β,γ-Distearoyl-α-phosphatidylethanolamine

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

CAS: 1069-79-0

Fórmula: C₄₁H₈₂NO₈P

Pureza: >97.0%(HPLC)(N)

Forma y color: White to Almost white powder to crystal

Peso molecular: 748.08

Ref: 3B-D4214

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate

CAS: 1069-79-0

Fórmula: C₄₁H₈₂NO₈P

Pureza: 97%

Forma y color: Solid

Peso molecular: 748.0654

Ref: IN-DA007BD0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

Pureza: ≥95%

Peso molecular: 748.07g/mol

Ref: 54-BUP18008

(2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Distearate

CAS: 1069-79-0

(2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Distearate

Pureza: 95%

Peso molecular: 748.07g/mol

Ref: 54-OR1007966

1,2-Distearoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 1069-79-0

Fórmula: C41H82NO8P

Pureza: >98%

Forma y color: Solid

Peso molecular: 748.07

Ref: 48-37-1820

1,2-Distearoyl-SN-Glycero-3-Phosphoethanolamine

CAS: 1069-79-0

Fórmula: C₄₁H₈₂NO₈P

Peso molecular: 748.08

Ref: 4Z-P-312003

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) is a phosphatidylethanolamine (PE or GPEtn) capable of being used in the synthesis of liposomes.

Fórmula: C₄₁H₈₂NO₈P

Pureza: ≥95%

Forma y color: Solid

Peso molecular: 748.07

Ref: TM-T5249

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

Pureza: 98%

Peso molecular: 748.08

Ref: 10-F986827

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

Producto controlado

CAS: 1069-79-0

Applications 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine is used in the generation of micelles and liposomes.
References Høyrup, P., et al.: Biochim. Biophys. Acta, 1515, 133 (2001); Heberle, F., et al.: Cold Spring Harb Perspect Biol., 3, 1 (2011)

Fórmula: C₄₁H₈₂NO₈P

Forma y color: Neat

Peso molecular: 748.07

Ref: TR-D493610

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine is an effector protein that functions to stabilize the extracellular matrix. It has been shown to be effective in the stabilization of lipid bilayers. This compound is a biocompatible polymer that can be used as a model system for studying dispersive solid phase extraction (DSPE). The phase transition temperature of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine is approximately -10°C. This property makes it suitable for use in applications where freeze/thaw cycles are required. The nitrogen atoms in this compound can react with alkanoic acids and liposomes to form stable complexes. These interactions are important pharmacokinetic properties of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine because they allow for the delivery of drugs into cells through

Fórmula: C₄₁H₈₂NO₈P

Pureza: Min. 95%

Peso molecular: 748.07 g/mol

Ref: 3D-FD178397