CAS 1075198-30-9

COMU

Descripción:

COMU, o 1-Ciano-1-(2,4,6-trimetilfenil)urea, es un compuesto químico utilizado principalmente como reactivo de acoplamiento en la síntesis de péptidos. Es conocido por su capacidad para facilitar la formación de enlaces amida entre ácidos carboxílicos y aminas, lo que lo hace valioso en la síntesis orgánica y la bioquímica. COMU se caracteriza por su estabilidad bajo diversas condiciones, lo que permite reacciones de acoplamiento eficientes sin necesidad de pasos de purificación excesivos. El compuesto típicamente exhibe buena solubilidad en disolventes orgánicos, lo que mejora su utilidad en entornos de laboratorio. Además, COMU es preferido por sus condiciones de reacción suaves y reacciones secundarias reducidas en comparación con otros agentes de acoplamiento. Su estructura incluye un grupo ciano y una parte de urea, lo que contribuye a su reactividad y efectividad en facilitar la formación de enlaces peptídicos. En general, COMU es un reactivo significativo en el campo de la química de péptidos, permitiendo la síntesis de péptidos complejos con altos rendimientos y pureza.

Fórmula: C₁₂H₁₉F₆N₄O₄P

InChI: InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

Clave InChI: GPDHNZNLPKYHCN-DZOOLQPHSA-N

SMILES: CCOC(=O)/C(=N\OC(=[N+](C)C)N1CCOCC1)/C#N.F[P-](F)(F)(F)(F)F

Sinónimos:

• 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium

COMU

CAS: 1075198-30-9

A safe and highly efficient coupling reagent requiring only one equivalent of base during bond formation as it liberates morpholine. This helps to minimize concomitant racemization. Non-allergenic. Couplings with COMU can be monitored visually or colorimetrically, the reagent shows excellent solubility in DMF and NMP. COMU is especially suited for microwave-accelerated SPPS.

Fórmula: C₁₂H₁₉F₆N₄O₄P

Forma y color: White

Peso molecular: 428.27

Ref: 01-4062545

{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosphate

CAS: 1075198-30-9

{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosphate

Fórmula: C₁₂H₁₉N₄O₄·PF₆

Pureza: 98%

Forma y color: Solid-Crystals

Peso molecular: 428.26784

Ref: 54-PC48468

N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate

CAS: 1075198-30-9

Fórmula: C₁₂H₁₉F₆N₄O₄P

Pureza: 98%

Forma y color: Solid

Peso molecular: 428.2678

Ref: IN-DA0034ML

COMU

CAS: 1075198-30-9

4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate(V)

Fórmula: C₁₂H₁₉F₆N₄O₄P

Pureza: 98%

Peso molecular: 428.27

Ref: IN-DG220226

COMU

CAS: 1075198-30-9

COMU is an uronium salt used as a coupling agent for peptide synthesis and phosphonamidation. COMU is safe, shows coupling effectiveness comparable to HATU, has an outstanding solubility in organic solvents such as DMF, can be conveniently used with just 1 equivalent of base, achieves great racemisation suppression and is compatible with microwave heating conditions. Additionally, its by-products are water-soluble which denotes ease of purification by extraction. A coupling reaction with COMU can be visually monitored showing colour change at its completion. The high reactivity of the dimethylmorpholino core together with the remarkable leaving group ability of the Oxyma moiety confer to COMU enhanced reactivity compared to benzotriazole-based analogues.

Fórmula: C₁₂H₁₉F₆N₄O₄P

Pureza: Min. 97 Area-%

Forma y color: White Powder

Peso molecular: 428.27 g/mol

Ref: 3D-FC15427

COMU Reagent

CAS: 1075198-30-9

COMU reagent is a copper-containing, natural compound that can be used in intrauterine diagnosis. The COMU reagent has been shown to have potent antagonistic activity against the CB2 receptor and hydrogen bond donor site. This product also can be used to detect the presence of peptide hormones, such as LH and FSH, in urine samples. The COMU reagent has been shown to bind to integrin receptors on cells, which are involved in cell adhesion and migration. The conformational properties of this compound allow it to form a complex with cyclic peptides that are found in human liver cells infected with hepatitis C virus (HCV).

Fórmula: C₁₂H₁₉N₄O₄F₆P

Pureza: Min. 95%

Peso molecular: 428.27 g/mol

Ref: 3D-KCM-1015-PI

(1-Cyano-2-ethoxy-2-oxoethylidene aminooxy)dimethylaminomorpholino carbenium hexafluorophosphate

CAS: 1075198-30-9

Fórmula: C₁₂H₁₉F₆N₄O₄P

Pureza: 96%

Forma y color: Solid

Peso molecular: 428.272

Ref: 10-F044578

N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate

Producto controlado

CAS: 1075198-30-9

Applications N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate is used as an efficient coupling agent in phosphonamidation reactions; used as coupling reagent in the synthesis of solid phase peptide
References Fredriksen, K., et al.: Eur. J. Org. Chem., 3, 474 (2016); Achyuthan, K., et al.: J. Pept. Sci., 21, 751 (2015);

Fórmula: C₁₂H₁₉N₄O₄·F₆P

Forma y color: Neat

Peso molecular: 428.27

Ref: TR-C797495