CAS 1088-11-5

2H-1,4-benzodiazepin-2-ona, 7-cloro-1,3-dihidro-5-fenil-

Descripción:

2H-1,4-benzodiazepin-2-ona, 7-cloro-1,3-dihidro-5-fenil- es un compuesto químico que pertenece a la clase de las benzodiazepinas, caracterizado por sus anillos fusionados de benceno y diazepina. Este compuesto típicamente exhibe propiedades como efectos sedantes, ansiolíticos y relajantes musculares, lo que lo hace relevante en farmacología. La presencia de un átomo de cloro en la posición 7 y un grupo fenilo en la posición 5 contribuye a su reactividad química única y actividad biológica. A menudo se estudia por sus posibles aplicaciones terapéuticas, particularmente en el tratamiento de la ansiedad y los trastornos del sueño. La estructura del compuesto permite interacciones con el sistema nervioso central, principalmente a través de la modulación de los receptores GABA, que son cruciales para la neurotransmisión inhibitoria. Además, su solubilidad y estabilidad pueden variar según las condiciones ambientales, influyendo en su biodisponibilidad y eficacia. Las precauciones de seguridad y manejo son esenciales debido a sus propiedades farmacológicas, y está sujeto a controles regulatorios en muchas jurisdicciones.

Fórmula: C₁₅H₁₁ClN₂O

InChI: InChI=1/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)

Clave InChI: InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(=NCC(=O)NC2=CC1)C3=CC=CC=C3

Sinónimos:

• 1-Demethyldiazepam
• 7-Chloro-1,3-dihydro-1H-5-phenyl-2H-1,4-benzodiazepin-2-one
• 7-Chloro-1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-one
• 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazapin-2-one
• 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
• 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one
• 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 7-Chloro-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
• 7-Chloro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
• 7-Chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
• 7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
• 7-Chloro-5-phenyl-2-oxo-1,2-dihydro-1,4-benzodiazepine
• 7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
• A 101
• Calmday
• Dealkylprazepam
• Demethyldiazepam
• Demoxazepam
• Desalkylprazepam
• Desmethyldiazepam
• Dmdz
• Madar
• N-Demethyldiazepam
• N-Deoxydemoxepam
• N-Descyclopropylmethylprazepam
• N-Desmethyldiazepam
• N1-Desmethyldiazepam
• N¹-Desmethyldiazepam
• Nordaz
• Nordazepam
• Nordiazepam
• Norprazepam
• Nsc 46078
• Nsc 631619
• Praxadium
• Ro 5-2180
• Sigma D 7282
• Stilny
• 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
• 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
• DIAZEPAM, DESMETHYL (RO 5-2180, NORDIAZE P
• 7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
• N-Deoxydemoxapam
• 1,4-BENZODIAZEPIN-2-ONE,7-CHLORO-1,3-DIHYDRO-5-PHENYL-
• NDD
• Nordiazepam solution
• Nordazepam CIV (50 mg) (7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)
• Methanol (test Nordiazepam,1.0mg/mL)
• Ro 52180434
• Chlordesmethyldiazepam
• 7-Chloro-1,3-dihydro-5-phenyl-
• Clorazepate (break down)
• 1,3-Dihydro-7-Chloro-5-Phenyl-2H-1
• DESMETHYLDIAZEPAM METHANOL SOLUTION
• Diazepam EP impurity A
• Desmethyldiazepam solution
• 1,3-Dihydro-7-Chloro-5-Phenyl-2H-1,4-Benzodiazepine-2-One
• DESMETHYLDIAZEPAM--DEA SCHEDULE IV ITEM
• NDZ
• 7-chloro-1,3-dihydro-5-phenyl-2h-4-benzodiazepin-2-one

Nordiazepam-d5 (phenyl-d5)

Producto controlado

CAS: 1088-11-5

Pureza: 99 atom % D

Forma y color: White Solid

Peso molecular: 275.75

Ref: 3U-D7149

Nordazepam (Nordiazepam) 0.1 mg/ml in Methanol

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Colourless

Peso molecular: 270.71

Ref: 61-AMP0023.02-02

Desmethyldiazepam (Nordazepam)

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: White To Light Yellow

Peso molecular: 270.71

Ref: 61-FOR0023.02

Desmethyldiazepam (Nordazepam), 1mg/ml in Methanol

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Single Solution

Peso molecular: 270.71

Ref: LP-DIA-108-1LM

Desmethyldiazepam (Nordazepam)

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Peso molecular: 270.71

Ref: LP-DIA-108

Desmethyldiazepam (Nordazepam)

Producto controlado

CAS: 1088-11-5

Forma y color: Neat

Ref: LP-DIA8

7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nordazepam)

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Neat

Peso molecular: 270.71

Ref: 86-MM0023.02

Nordazepam (Nordiazepam) 1.0 mg/ml in Methanol

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Colourless

Peso molecular: 270.71

Ref: 61-AMP0023.02-01

Nordazepam

Producto controlado

CAS: 1088-11-5

Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).
References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Neat

Peso molecular: 270.71

Ref: TR-D291595

Diazepam EP Impurity A

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Peso molecular: 270.71

Ref: ST-EA-CP-D18001

Nordazepam (1.0 mg/mL in Methanol)

Producto controlado

CAS: 1088-11-5

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Single Solution

Peso molecular: 270.71

Ref: TR-KIT0645

Nordazepam

Producto controlado

CAS: 1088-11-5

Alprazolam(inn), camazepam (inn), chlordiazepoxide (inn), clonazepam (inn), clorazepate & other heterocyclic compounds with nitro atom(s) only

Fórmula: C₁₅H₁₁ClN₂O

Forma y color: Light Yellow White Powder

Peso molecular: 270.05599

Ref: 45-1468400

Desmethyl diazepam

Producto controlado

CAS: 1088-11-5

Diazepam is a long-acting benzodiazepine drug that is used for the treatment of a variety of conditions, such as anxiety, insomnia, muscle spasms, and alcohol withdrawal. Diazepam has been shown to have anti-convulsant properties. The hydroxyl group on diazepam's side chain is converted to an ester in order to make it more lipid soluble and therefore more readily absorbed by the body. This conversion occurs partially through the action of enzymes found in the liver microsomes of rats and humans. Desmethyldiazepam (DMDZ) is formed from diazepam by the enzyme monoamine oxidase (MAO). DMDZ has similar pharmacological properties to its parent compound but with a shorter duration of action. Maternal blood levels of DMDZ are higher than those found in serum or plasma, which may be due to differences in protein binding between these two compartments.

Fórmula: C₁₅H₁₁ClN₂O

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 270.71 g/mol

Ref: 3D-FD21258