CAS 117977-21-6

Rabeprazol-tioéter

Descripción:

Rabeprazol-tioéter es un derivado del rabeprazol, un inhibidor de la bomba de protones comúnmente utilizado para tratar condiciones como la enfermedad por reflujo gastroesofágico (ERGE) y las úlceras pépticas. Este compuesto presenta un grupo funcional tioéter, que puede influir en sus propiedades farmacológicas, incluida la solubilidad y la estabilidad metabólica. El rabeprazol en sí es conocido por su capacidad para inhibir la enzima H+/K+ ATPasa en las células parietales gástricas, reduciendo así la secreción de ácido gástrico. La modificación tioéter puede mejorar su biodisponibilidad o alterar su interacción con los objetivos biológicos. Típicamente, compuestos como Rabeprazol-tioéter se caracterizan por su peso molecular, fórmula estructural y grupos funcionales específicos, que contribuyen a su reactividad química y eficacia terapéutica. Además, la estabilidad del compuesto, la solubilidad en varios disolventes y los posibles efectos secundarios son características importantes que a menudo se evalúan durante el desarrollo de medicamentos y el uso clínico. En general, Rabeprazol-tioéter representa una modificación destinada a optimizar los efectos terapéuticos del rabeprazol mientras se minimizan potencialmente los efectos adversos.

Fórmula: C₁₈H₂₁N₃O₂S

InChI: InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)

Clave InChI: InChIKey=BSXAHDOWMOSVAP-UHFFFAOYSA-N

SMILES: S(CC1=C(C)C(OCCCOC)=CC=N1)C=2NC=3C(N2)=CC=CC3

Sinónimos:

• 1H-Benzimidazole,2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-
• 2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
• 2-[((4-(3-Methoxypropoxy)-3-methylpyridine-2-yl)methyl)thio]-1H-benzimidazole
• 2-[[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole
• 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole
• 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole
• 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
• H 295/43
• Rabeprazole-thioether

Rabeprazole Sulfide

CAS: 117977-21-6

Fórmula: C₁₈H₂₁N₃O₂S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 343.45

Ref: 3B-R0098

Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole)

CAS: 117977-21-6

Aromatic or modified aromatic heterocyclic compounds wi

Fórmula: C₁₈H₂₁N₃O₂S

Forma y color: White Off-White Powder

Peso molecular: 343.13545

Ref: 45-1598064

2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole

CAS: 117977-21-6

Fórmula: C₁₈H₂₁N₃O₂S

Pureza: 98%

Forma y color: Solid

Peso molecular: 343.4432

Ref: IN-DA007QM8

2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Methylthio}-1H-Benzimidazole

CAS: 117977-21-6

2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Methylthio}-1H-Benzimidazole

Pureza: 98%

Peso molecular: 343.44g/mol

Ref: 54-OR1010226

Rabeprazole EP Impurity B (Rabeprazole Sulfide)

CAS: 117977-21-6

Fórmula: C₁₈H₂₁N₃O₂S

Forma y color: White To Off-White Solid

Peso molecular: 343.45

Ref: 4Z-R-205

Rabeprazole Sulfide

CAS: 117977-21-6

Rabeprazole Sulfide

Pureza: ≥98%

Peso molecular: 343.44g/mol

Ref: 54-BUP17604

2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole

Producto controlado

CAS: 117977-21-6

Forma y color: Neat

Ref: 86-MM0618.02

Rabeprazole Sulfide

CAS: 117977-21-6

Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors.

Fórmula: C₁₈H₂₁N₃O₂S

Pureza: 99.34% - 99.78%

Forma y color: Off-White Crystalline Powder

Peso molecular: 343.44

Ref: TM-T1734

Rabeprazole Sulfide

CAS: 117977-21-6

Impurity Rabeprazole EP Impurity B
Applications Rabeprazole Sulfide (Rabeprazole EP Impurity B) is a metabolite of Rabeprazole (R070500).
References Yoshida, T., et al.: Biotech. Lett., 23, 1217 (2001), Miura, M., et al.: Eur. J. Clin. Pharmacol., 62, 113 (2006), Sheridan, R.P., et al.: J. Med. Chem., 50, 3173 (2007), Ren, S., et al.: Arc. Pharm. Res., 31, 406 (2008),

Fórmula: C₁₈H₂₁N₃O₂S

Forma y color: Neat

Peso molecular: 343.45

Ref: TR-R070510

Rabeprazole EP Impurity B

CAS: 117977-21-6

Fórmula: C₁₈H₂₁N₃O₂S

Peso molecular: 343.44

Ref: ST-EA-CP-R5002

2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole

CAS: 117977-21-6

Pureza: 95.0%

Forma y color: Solid

Peso molecular: 343.45001220703125

Ref: 10-F078879

2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole

CAS: 117977-21-6

Rabeprazole is a proton pump inhibitor that is used to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcers. Rabeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium ATPase that is found in the parietal cells of the stomach. The main mechanism of action for rabeprazole is competitive inhibition of the proton pump, which leads to decreased gastric acid secretion. Rabeprazole can be administered orally or intravenously, with a half-life of about 2 hours. It has been shown to have an effect on human liver cytochrome P450s, but does not affect the activity of recombinant cytochrome P450 3A4 (CYP3A4). In clinical studies, rabeprazole was shown to have no adverse effects on CYP3A4 activity and may even increase it slightly.

Fórmula: C₁₈H₂₁N₃O₂S

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 343.44 g/mol

Ref: 3D-IM57863

Rabeprazole-D4 Sulfide

Producto controlado

CAS: 117977-21-6

Applications Rabeprazole-D4 Sulfide is an intermediate in the synthesis of Rabeprazole-d4 (R070492). Rabeprazole-D4 Sulfide is an isotope-labeled analogue of Rabeprazole Sulfide (Rabeprazole EP Impurity B), which is a metabolite of Rabeprazole (R070500).
References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)

Fórmula: C₁₈D₄H₁₇N₃O₂S

Forma y color: Neat

Peso molecular: 347.468

Ref: TR-R070511