CAS 1223405-08-0

Fórmula: C21H24F2N6O6S

InChI: InChI=1S/C21H22F2N6O2.H2O4S/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27;1-5(2,3)4/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31);(H2,1,2,3,4)/t14-,18+;/m0./s1

Clave InChI: PXHANKVTFWSDSG-QLOBERJESA-N

SMILES: C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O

Larotrectinib sulfate

CAS: 1223405-08-0

Larotrectinib sulfate

Fórmula: C₂₁H₂₂F₂N₆O₂·H₂O₄S

Pureza: 99.5%

Peso molecular: 526.51

Ref: 54-BUP13049

Larotrectinib Sulfate

Producto controlado

CAS: 1223405-08-0

Applications Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).
References Anon.: Cancer Discovery, 6, 4 (2016); Passiglia, F., et al.: Expert Opin. Investig. Drugs, 25, 385 (2016)

Fórmula: C₂₁H₂₂F₂N₆O₂·(H₂O₄S)

Forma y color: Neat

Peso molecular: 526.5

Ref: TR-L175933

Larotrectinib Sulfate

CAS: 1223405-08-0

Fórmula: C₂₁H₂₂F₂N₆O₂·H₂O₄S

Peso molecular: 428.44 98.07

Ref: 4Z-L-160015

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate

CAS: 1223405-08-0

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate

Fórmula: C₂₁H₂₄F₂N₆O₆S

Pureza: 98%

Peso molecular: 526.51

Ref: IN-DG630018

Larotrectinib sulfate

CAS: 1223405-08-0

Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).

Fórmula: C₂₁H₂₄F₂N₆O₆S

Pureza: 98.62% - 99.76%

Forma y color: Solid

Peso molecular: 526.51

Ref: TM-T6880

Larotrectinib sulphate

CAS: 1223405-08-0

A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.

Fórmula: C₂₁H₂₂F₂N₆O₂H₂SO₄

Pureza: Min. 95%

Peso molecular: 526.51 g/mol

Ref: 3D-BL161518

1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-, sulfate (1:1)

CAS: 1223405-08-0

Fórmula: C₂₁H₂₄F₂N₆O₆S

Pureza: 98%

Forma y color: Solid

Peso molecular: 526.5137

Ref: IN-DA00174F