CAS 125317-39-7: Navelbine

Descripción: Navelbine, conocido por su nombre genérico vinorelbine, es un alcaloide de vinca semisintético derivado de la planta de vincapervinca, Catharanthus roseus. Se utiliza principalmente como agente quimioterapéutico en el tratamiento de varios tipos de cáncer, incluyendo cáncer de pulmón de células no pequeñas y cáncer de mama. Vinorelbine funciona inhibiendo la formación de microtúbulos durante la división celular, interrumpiendo así el huso mitótico y llevando a la detención del ciclo celular y apoptosis en células cancerosas que se dividen rápidamente. El compuesto se administra típicamente por vía intravenosa y tiene un perfil de efectos secundarios moderado, que puede incluir neutropenia, náuseas y fatiga. Su farmacocinética implica metabolismo hepático, principalmente a través del sistema del citocromo P450, y se excreta principalmente en la bilis. El número CAS 125317-39-7 identifica de manera única a vinorelbine en bases de datos químicas, facilitando la investigación y aplicaciones clínicas. En general, Navelbine representa una opción terapéutica importante en oncología, contribuyendo a mejorar los resultados en pacientes con malignidades específicas.

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

InChI: InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

Clave InChI: InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES: O=C(O)C(O)C(O)C(=O)O.O=C(OC1C(O)(C(=O)OC)C2N(C3=CC(OC)=C(C=C3C42CCN5CC=CC1(CC)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CN9CC(=CC(C9)C6)CC)C)C

Sinónimos:

• (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
• 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
• 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
• 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
• 5'-Noranhydrovinoblastine Tartrate
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Bitartrate
• Butanedioate(1:2)
• C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
• Kw 2307
• Navelbine
• Navelbine ditartrate
• Navelbine tartrate
• Nor-5′-anhydrovinblastine ditartrate
• Nvb
• Pacilitaxel
• Vinorelbin
• Vinorelbine bitartrate
• Vinorelbine bitratrate
• Vinorelbine ditartaric acid
• Vinorelbine ditartrate salt
• Vinorelbine tartarate
• Vinorelbine tartrate
• Vinorelbine tartrate usp standard
• Vinorelbineditartrate salt hydrate
• [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• Vinorelbine ditartrate

Vinorelbine for peak identification B CRS

CAS: 125317-39-7

• Forma y color: Powder

Vinorelbine for peak identification A CRS

CAS: 125317-39-7

• Forma y color: Powder

Vinorelbine tartrate CRS

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈
• Forma y color: Powder
• Peso molecular: 778.9323

Vinorelbine Tartrate

CAS: 125317-39-7

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

• Fórmula: C₄₅H₅₄N₄O₈· 2C₄H₆O₆
• Forma y color: Powder
• Peso molecular: 778.39416

Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

CAS: 125317-39-7

• Fórmula: C₅₃H₆₇N₄O₂₀
• Forma y color: Solid
• Peso molecular: 1080.1139

Vinorelbine Ditartrate Salt

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Pureza: 98%
• Forma y color: white to off-white solid
• Peso molecular: 1,079.11g/mol

Vinorelbine Ditartrate

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Forma y color: White To Off-White Solid
• Peso molecular: 778.95 2*150.09

Vinorelbine Ditartrate

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Pureza: >95.0%(T)(HPLC)
• Forma y color: White to Light yellow powder to crystal
• Peso molecular: 1,079.12

Vinorelbine Tartrate

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Forma y color: Neat
• Peso molecular: 1079.11

Vinorelbine Tartrate

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈•2C₄H₆O₆
• Pureza: 95%~99%
• Peso molecular: 1079.11

Vinorelbine tartrate

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Forma y color: Neat
• Peso molecular: 1079.11

Vinorelbine tartrate, 98%

CAS: 125317-39-7

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Fórmula: C₅₃H₆₆N₄O₂₀
• Pureza: 98%
• Forma y color: White to almost white, Powder
• Peso molecular: 1079.12

Vinorelbine ditartrate

CAS: 125317-39-7

• Fórmula: C₄₅H₅₄N₄O₈· 2C₄H₆O₆·xH₂O
• Pureza: (HPLC) ≥ 98.0% (dried basis)
• Forma y color: White to off-white powder
• Peso molecular: 1079.11 (anhydrous)

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor …

• Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Pureza: 98% - 99.86%
• Forma y color: White To Off-White Crystalline Powder
• Peso molecular: 1079.11

Vinorelbine Bitartrate

CAS: 125317-39-7

Stability Temperature Sensitive Applications An antineoplastic. References Mathe, G., et al.: Cancer Letters, 27, 285 …

• Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Forma y color: White
• Peso molecular: 1079.11

Vinorelbine-d3 Bitartrate

CAS: 125317-39-7

Stability Light Sensitive, Temperature Sensitive Applications An antineoplastic. Not a dangerous good if item is …

• Fórmula: C₅₃H₆₃D₃N₄O₂₀
• Forma y color: Neat
• Peso molecular: 1082.12

Vinorelbine tartrate - Bio-X ™

CAS: 125317-39-7

This product is part of our Bio-X ™ Range. These products are aimed at life …

• Fórmula: C₅₃H₆₆N₄O₂₀
• Pureza: Min. 95%
• Forma y color: Powder
• Peso molecular: 1,079.11 g/mol

Vinorelbine tartrate

CAS: 125317-39-7

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

• Fórmula: C₅₃H₆₆N₄O₂₀
• Pureza: (Hplc) Min. 98.0%
• Forma y color: White Powder
• Peso molecular: 1,079.11 g/mol