CAS 128270-60-0

Bivalirudina

Descripción:

Bivalirudina es un péptido sintético que funciona como un inhibidor directo de la trombina, utilizado principalmente como anticoagulante en entornos clínicos, particularmente durante intervenciones coronarias percutáneas. Su estructura consiste en 20 aminoácidos y se deriva del péptido hirudina encontrado en las sanguijuelas. Bivalirudina exhibe una alta afinidad por la trombina, previniendo eficazmente la conversión de fibrinógeno a fibrina, lo cual es crucial en el proceso de coagulación. La sustancia se administra por inyección intravenosa y tiene una vida media relativamente corta, lo que requiere un monitoreo cuidadoso de los niveles de anticoagulación durante el tratamiento. Bivalirudina se caracteriza por su estabilidad en el torrente sanguíneo y su capacidad para proporcionar anticoagulación rápida con un perfil farmacocinético predecible. A menudo se prefiere sobre los anticoagulantes tradicionales debido a su menor riesgo de inducir trombocitopenia y su facilidad de uso en pacientes con función renal variable. En general, Bivalirudina representa un avance significativo en la terapia anticoagulante, particularmente en el manejo del síndrome coronario agudo.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

InChI: InChI=1/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1

Sinónimos:

• L-leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-
• D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine
• Bivalirudin,TFA
• Bivalirudin Trifluoroacetate

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a highly specific and reversible direct thrombin inhibitor.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 98.9%

Forma y color: White

Peso molecular: 2180.32

Ref: 01-4049766

Bivalirudin

CAS: 128270-60-0

Cardiovascular drugs, not elsewhere specified or included

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Forma y color: White Off-White Powder

Peso molecular: 2178.98581

Ref: 45-1076013

L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 2180.2853

Ref: IN-DA000XXZ

Bivalirudin

CAS: 128270-60-0

Bivalirudin

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Forma y color: Solid-Powder

Peso molecular: 2180.28531

Ref: 54-BITP1474

Bivalirudin

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Forma y color: White To Off-White Solid

Peso molecular: 2180.32

Ref: 4Z-PB-122001

Bivalirudin

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Peso molecular: 2180.29

Ref: 7W-GP4765

Bivalirudin Trifluoroacetate

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 95%~99%

Forma y color: White to Off-white Powder

Peso molecular: 2180.29

Ref: BP-BPPG010

Bivalirudin

CAS: 128270-60-0

Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 98.80% - >99.99%

Forma y color: White To Off-White Powder

Peso molecular: 2180.29

Ref: TM-T5519

Bivalirudin

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Peso molecular: 2180.32

Ref: ST-EA-CP-B103001

Bivalirudin

CAS: 128270-60-0

Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: Min. 95%

Forma y color: White Solid

Peso molecular: 2178.98581

Ref: 3D-FB29604

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a synthetic cyclic peptide that binds to the ATP-binding cassette transporter and inhibits the activity of the proteolytic enzyme, angiotensin-converting enzyme (ACE). ACE inhibition prevents the conversion of angiotensin I to angiotensin II. Bivalirudin has been shown to be effective in reducing mortality in patients with acute coronary syndrome or undergoing percutaneous coronary intervention. It has also been shown to have pharmacokinetic properties that are similar to those of heparin. The drug has a low dose and is not associated with an increased risk of bleeding. Bivalirudin is an inhibitor and can cause drug interactions when combined with other drugs that are inhibitors or substrates for this type of transporter.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: Min. 95%

Peso molecular: 2,180.33 g/mol

Ref: 3D-BIV-3767-PI

Bivalirudin 1-11 Fragment Trifluoroacetic Acid Salt

Producto controlado

CAS: 128270-60-0

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Fórmula: C₄₃H₆₃N₁₅O₁₅·(C₂HF₃O₂)x

Forma y color: Neat

Peso molecular: 1030.0511402

Ref: TR-B591640