CAS 1332391-11-3

Fórmula: C20H13F4N5O2S

InChI: InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)

Clave InChI: BAANHOAPFBHUDX-UHFFFAOYSA-N

SMILES: C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

Fórmula: C₂₀H₁₃F₄N₅O₂S

Pureza: 98.6%

Forma y color: Solid

Peso molecular: 463.408

Ref: TM-T12146

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide

Fórmula: C₂₀H₁₃F₄N₅O₂S

Pureza: ≥95%

Peso molecular: 463.41

Ref: 54-BUP08683

N-Desmethyl Apalutamide

CAS: 1332391-11-3

Fórmula: C₂₀H₁₃F₄N₅O₂S

Forma y color: White To Off-White Solid

Peso molecular: 463.41

Ref: 4Z-A-284003

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Fórmula: C₂₀H₁₃F₄N₅O₂S

Pureza: 98%

Peso molecular: 463.4081

Ref: IN-DA01NV7R

N-Desmethyl Apalutamide

Producto controlado

CAS: 1332391-11-3

Applications N-Desmethyl Apalutamide has been exploresd asthiohydantion androgen receptor antagonist for treament of cancer
References Bignan, G.C. PCT Int. Appl. (2018), WO 2018037342 A1 20180301.

Fórmula: C₂₀H₁₃F₄N₅O₂S

Forma y color: Neat

Peso molecular: 463.41

Ref: TR-D291395

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide

Fórmula: C₂₀H₁₃F₄N₅O₂S

Pureza: 98%

Peso molecular: 463.41

Ref: IN-DG01289413

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Fórmula: C₂₀H₁₃F₄N₅O₂S

Peso molecular: 463.4

Ref: BE-RMCA245002

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Fórmula: C₂₀H₁₃F₄N₅O₂S

Peso molecular: 463.41

Ref: ST-EA-CP-A92016

N-Desmethyl Apalutamide-d4

Producto controlado

CAS: 1332391-11-3

Fórmula: C₂₀D₄H₉F₄N₅O₂S

Forma y color: Neat

Peso molecular: 467.433

Ref: TR-D291398

N-Desmethyl Apalutamide D-13C215N

Producto controlado

CAS: 1332391-11-3

Fórmula: C₂C₁₈H₁₃F₄₁₅NN₄O₂S

Forma y color: Neat

Peso molecular: 466.387

Ref: TR-D291397

N-Desmethyl-apalutamide

CAS: 1332391-11-3

Apalutamide is a nonsteroidal antiandrogen that binds to the androgen receptor in prostate cancer cells. It has been shown to inhibit the proliferation of human prostate cancer cell lines and tumor xenografts in nude mice. Apalutamide is a potent inhibitor of protein interactions with the androgen receptor, which may be due to its ability to compete with testosterone for binding sites. It also has an activating effect on the androgen receptor, leading to increased transcription of genes regulated by this receptor.

Fórmula: C₂₀H₁₃F₄N₅O₂S

Pureza: Min. 95%

Peso molecular: 463.4 g/mol

Ref: 3D-HDC39111