CAS 137281-23-3

Pemetrexed

Descripción:

Pemetrexed es un agente quimioterapéutico antifolato de múltiples objetivos que se utiliza principalmente en el tratamiento de ciertos tipos de cáncer, particularmente el cáncer de pulmón de células no pequeñas y el mesotelioma. Su mecanismo de acción implica la inhibición de varias enzimas en la vía del folato, incluyendo la timidilato sintasa, la dihidrofolato reductasa y la formiltransferasa de ribonucleótido de glicinamida, que son cruciales para la síntesis de ADN y la proliferación celular. Pemetrexed se administra por vía intravenosa y a menudo se combina con otros agentes quimioterapéuticos para mejorar su eficacia. El fármaco se caracteriza por su complejidad estructural, que presenta un anillo de pirimidina y múltiples grupos funcionales que contribuyen a su actividad biológica. Los efectos secundarios comunes incluyen mielosupresión, trastornos gastrointestinales y fatiga, lo que requiere un monitoreo cuidadoso durante el tratamiento. Además, los pacientes pueden necesitar suplementación con ácido fólico y vitamina B12 para mitigar algunas de las toxicidades del fármaco. En general, Pemetrexed representa un avance significativo en la terapia dirigida contra el cáncer, demostrando mejores resultados en poblaciones de pacientes específicas.

Fórmula: C₂₀H₂₁N₅O₆

InChI: InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1

Clave InChI: InChIKey=WBXPDJSOTKVWSJ-ZDUSSCGKSA-N

SMILES: C(CC1=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)C=2C3=C(NC2)NC(N)=NC3=O

Sinónimos:

• (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
• 1H-Pyrrolo[2,3-d]pyrimidine, <span class="text-smallcaps">L</span>-glutamic acid deriv.
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H pyrodo[2,3-d]Pyrimidin-5-yl)ethyl]-benzoic Acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
• N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid
• N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
• NSC 698037
• Pefloxacinmesylate Pharma-0549
• Pemetrexed
• Pemetrexed Acid
• disodium (2R)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

Pemetrexed

CAS: 137281-23-3, 1916503-69-9

Fórmula: C₂₀H₂₁N₅O₆

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Blue powder to crystal

Peso molecular: 427.42

Ref: 3B-P2288

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid

CAS: 137281-23-3

Fórmula: C₂₀H₂₁N₅O₆

Pureza: %

Forma y color: Solid

Peso molecular: 427.4106

Ref: IN-DA00131R

Pemetrexed Hydrate

CAS: 137281-23-3

Pemetrexed Hydrate

Fórmula: C₂₀H₂₁N₅O₆

Pureza: >99%

Forma y color: Solid

Peso molecular: 427.41

Ref: 54-OR1030044

Pemetrexed

CAS: 137281-23-3

Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 98.1% - 99.92%

Forma y color: Solid

Peso molecular: 427.41

Ref: TM-T0189

Pemetrexed

CAS: 137281-23-3

Pemetrexed

Fórmula: C₂₀H₂₁N₅O₆

Pureza: ≥98%

Peso molecular: 427.41

Ref: 54-BUP17815

Pemetrexed

CAS: 137281-23-3

Fórmula: C₂₀H₂₁N₅O₆

Forma y color: White To Off-White Solid

Peso molecular: 427.42

Ref: 4Z-P-681

Pemetrexed

CAS: 137281-23-3

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 99+%

Peso molecular: 427.41

Ref: IN-DG146899

Pemetrexed

CAS: 137281-23-3

Fórmula: C₂₀H₂₁N₅O₆

Peso molecular: 427.42

Ref: ST-EA-CP-P16000

Pemetrexed

CAS: 137281-23-3

Thymidylate synthase inhibitor; antifolate antineoplastic agent

Fórmula: C₂₀H₂₁N₅O₆

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 427.41 g/mol

Ref: 3D-FP37935

Pemetrexed-[13C5]

CAS: 137281-23-3

Ref: BE-MC-7261

Pemetrexed

CAS: 137281-23-3

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 98% +(contains <4%EtOH)(Loss on drying≤6%)

Peso molecular: 427.41

Ref: IN-DG01386674

Pemetrexed (Standard)

CAS: 137281-23-3

Pemetrexed (Standard) is a reference standard for research and analysis in studies involving Pemetrexed. Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Fórmula: C₂₀H₂₁N₅O₆

Forma y color: Solid

Peso molecular: 427.41

Ref: TM-TMSM-3442

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid

Producto controlado

CAS: 137281-23-3

Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).
References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);

Fórmula: C₂₀H₂₁N₅O₆

Forma y color: Neat

Peso molecular: 427.41

Ref: TR-A604980

Pemetrexed - Bio-X ™

CAS: 137281-23-3

Pemetrexed is a chemotherapy drug that belongs to the class of drugs called folate antimetabolites. It is used for the treatment of various cancers such as non-small cell lung cancer and pleural mesothelioma. Pemetrexed targets the enzymes thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. The drug works by inhibiting those enzymes so that the formation of DNA and RNA is prevented.

Fórmula: C₂₀H₂₁N₅O₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 427.41 g/mol

Ref: 3D-BP164240