CAS 13870-90-1

Coenzima B12

Descripción:

Coenzima B12, también conocido como metilcobalamina, es un cofactor vital en varios procesos bioquímicos, particularmente en el metabolismo de la homocisteína y la síntesis de metionina. Es una vitamina soluble en agua que pertenece al complejo de vitaminas B, específicamente al grupo B12, que incluye varias formas de cobalamina. Caracterizado por su estructura compleja, Coenzima B12 contiene un ion de cobalto en su núcleo, coordinado a un anillo de corrina, y se distingue por la presencia de un grupo metilo. Este compuesto juega un papel crucial en el metabolismo celular, particularmente en el sistema nervioso central y en la formación de glóbulos rojos. La deficiencia de Coenzima B12 puede llevar a problemas de salud significativos, incluyendo anemia y trastornos neurológicos. Se obtiene principalmente a través de fuentes dietéticas, particularmente productos de origen animal, y es esencial para mantener una función neurológica adecuada y la síntesis de ADN. Además, Coenzima B12 se utiliza a menudo en entornos clínicos para tratar deficiencias y condiciones de salud relacionadas.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

InChI: InChI=1/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2

Clave InChI: InChIKey=OAJLVMGLJZXSGX-RQKYJTTQSA-L

SMILES: [CH2-]([Co+3]1234[N]=5[C@@]6(C)[C@@]7([N-]1C([C@@](C)([C@H]7CC(N)=O)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@H]8C(O)([C@@H](N9C=[N]2C=%10C9=CC(C)=C(C)C%10)O[C@@H]8CO)[H])=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5[C@@H](CCC(N)=O)[C@@]6(CC(N)=O)C)[C@](CC(N)=O)(C)[C@@H]%12CCC(N)=O)C(C)(C)[C@@H]%11CCC(N)=O)[H])[C@H]%13O[C@H]([C@H](O)[C@@H]%13O)N%14C=%15C(N=C%14)=C(N)N=CN%15

Sinónimos:

• (5'-Deoxy-5'-adenosyl)cobamide coenzyme
• (5,6-Dimethylbenzimidazolyl)Cobamide Coenzyme
• 5'-Deoxy-5'-adenosylcobalamin
• 5'-Deoxyadenosyl vitamin B12
• 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
• 5'-Deoxyadenosylcobalamin
• 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
• 5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
• 5′-Deoxyadenosyl vitamin B₁₂
• Actimide
• Adenosyl B12
• Adenosyl B₁₂
• Adenosylcobalamin
• Anabasi
• Betarin
• Calomide
• Cobalamin coenzyme
• Cobalamin, Co-(5'-deoxy-5'-adenosyl)-
• Cobalion
• Cobamamid
• Cobamamida
• Cobamamide
• Cobamide coenzyme, (5'-deoxy-5'-adenosyl)-
• Cobamide coenzyme, (5,6-dimethyl-1H-benzimidazolyl)-
• Cobamide, Co-(5'-deoxy-5'-adenosyl)-α-(5,6-dimethyl-1H-benzimidazolyl)-
• Cobanzyme
• Cobatlamin S
• Cobazymase
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') derivative hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Coenzile
• Coenzyme B12
• Coenzyme B₁₂
• DBC
• DBC coenzyme
• Dbcc
• Deoxyadenosylcobalamin
• Dibencozide
• Dibenzcozamide
• Dimebenzcozamide
• Dolonevran
• Enzicoba
• Funacomide
• Heraclene
• Hi-Fresmin
• Hycobal
• Indusil
• Lm 176
• Represil
• Sabalamin
• Vitamin B12 coenzyme
• Vitamin B12, Co-(5'-deoxy-5'-adenosyl) deriv.
• Vitamin B₁₂ coenzyme
• Vitamin B₁₂, Co-(5′-deoxy-5′-adenosyl) deriv.
• Xobaline
• α-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
• α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
• coenzyme B12 crystalline
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• adenosyl cobalamine
• 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• DMBC COENZYME
• CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
• ADENOSYLCOBALAMINE(COENZYME B12)(P)
• cobalaminecoenzyme
• Coenzyme B
• 2
• ADENOSYLCOBALAMINE(COENZYME B12)(RG)
• 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
• Cobamamide/VitaminB12
• Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• 5’-deoxyadenosylvitaminb12
• COBAMIDE
• COBAMAMIDE/DIBENCOZIDE
• DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
• COBAMAMIDE (PYROGEN FREE)
• cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
• ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
• lm176
• ADENOSYLCOBALAMINE(COENZYME B12)(AS)
• 1
• dbccoenzyme
• COENZYME B12, >=97.0%

Cobamamide

CAS: 13870-90-1

Vitamin b12 (cyanocobalamin and related compounds with vitamin b12 activity) and its derivatives

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Forma y color: Powder

Peso molecular: 1578.65834

Ref: 45-1142195

Adenosylcobalamin

CAS: 13870-90-1

AdoCbl is an active form of vitamin B12, a corrinoid, and cofactor for enzymes like methylmalonyl CoA mutase. Produced by select bacteria/archaea.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: 95.29% - 99.46%

Forma y color: Solid

Peso molecular: 1579.5818

Ref: TM-T14128

Coenzyme B12

CAS: 13870-90-1

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: (HPLC) 98.0 - 102.0 % (dried basis)

Forma y color: Dark red powder or crystalline powder

Peso molecular: 1579.58

Ref: 7W-GP8985

Cobamamide (Dibencozide, Coenzyme B12)

CAS: 13870-90-1

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Forma y color: Red Solid

Peso molecular: 1579.66

Ref: 4Z-C-161001

Cobamamide

Producto controlado

CAS: 13870-90-1

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Forma y color: Neat

Peso molecular: 1579.58

Ref: 04-C11692190

Cobamamide

Producto controlado

CAS: 13870-90-1

Applications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Forma y color: Neat

Peso molecular: 1579.58

Ref: TR-C633130

Coenzyme B12

CAS: 13870-90-1

Coenzyme B12, also known as vitamin B12, is a coenzyme that participates in the metabolism of amino acids and fatty acids. It is required for the conversion of homocysteine to methionine, which is an important step in the synthesis of S-adenosylmethionine (SAM), a major methyl donor. Coenzymes are required for many different reactions in cells, but they are not consumed during these reactions. Instead, they are regenerated and reused. Coenzyme B12 is synthesized by bacteria and archaea but not by animals. The cobalamin form of this coenzyme is made from cobaltous chloride or cobaltous sulfate and cyanide. This coenzyme has been shown to bind to riboswitches in bacteria and to ATP-binding cassette transporters in humans. Coenzyme B12 can exist in two different forms: adenosylcobalamin and methylcobalamin.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: Min. 97 Area-%

Forma y color: Powder

Peso molecular: 1,579.58 g/mol

Ref: 3D-FD65841