CAS 1397-89-3: Anfotericina B

Descripción: Anfotericina B es un agente antifúngico polieno que se utiliza principalmente para tratar infecciones fúngicas graves, particularmente aquellas causadas por especies de Candida y Aspergillus. Se deriva de la bacteria Streptomyces nodosus y es conocido por su capacidad para unirse al ergosterol, un componente clave de las membranas celulares fúngicas, lo que lleva a la interrupción de la membrana celular y, en última instancia, a la muerte celular. Anfotericina B se caracteriza por su color marrón amarillento y se administra típicamente por vía intravenosa debido a su baja biodisponibilidad oral. Tiene un peso molecular relativamente alto y es soluble en dimetilsulfóxido (DMSO) y otros disolventes orgánicos, pero poco soluble en agua. El fármaco es conocido por sus posibles efectos secundarios, incluyendo nefrotoxicidad y reacciones relacionadas con la infusión, lo que requiere un monitoreo cuidadoso durante el tratamiento. Anfotericina B se utiliza a menudo en casos severos donde otros tratamientos antifúngicos pueden ser ineficaces, lo que lo convierte en una opción crítica en el manejo de infecciones fúngicas invasivas.

Fórmula: C₄₇H₇₃NO₁₇

InChI: InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

Clave InChI: InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N

SMILES: O=C(O)C1C(O)CC2(O)OC1CC(OC3OC(C)C(O)C(N)C3O)C=CC=CC=CC=CC=CC=CC=CC(C)C(O)C(C)C(OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)C2)C

Sinónimos:

• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• Abelcet
• Abelecet
• AmBisome
• Ampho-Moronal
• Amphocin
• Amphozone
• Apothecon
• Fungilin
• Fungizona
• Fungizone
• Halizon
• Kalsome 10
• LNS-AmB
• Ns 718
• Nsc 527017
• amfotericina B
• amphotericine B
• Amphotericin B

Amphotericin B, Antibiotic for Culture Media Use Only

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is …

• Fórmula: C₄₇H₇₃NO₁₇
• Pureza: Min. 80.0 Area-%
• Peso molecular: 924.08 g/mol

Amphotericin B

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is …

• Fórmula: C₄₇H₇₃NO₁₇
• Forma y color: Yellow Powder
• Peso molecular: 924.08 g/mol

Amphotericin B (~80%)

CAS: 1397-89-3

Stability Hygroscopic Applications Amphotericin B is a polypeptide antibiotic active against gram positive bacteria. It …

• Fórmula: C₄₇H₇₃NO₁₇
• Pureza: ~80%
• Forma y color: Neat
• Peso molecular: 924.08

Amphotericin B (AMT) Solution (250ug/ml) for cell culture, Endotoxin (BET) 1EU/ml

CAS: 1397-89-3

• Fórmula: C₄₇H₇₃NO₁₇
• Forma y color: Clear, Colourless, Liquid
• Peso molecular: Â 924.09

Amphotericin B (AMT)

CAS: 1397-89-3

• Fórmula: C₄₇H₇₃NO₁₇
• Forma y color: Yellow to orange, Powder
• Peso molecular: 924.09