CAS 1397-89-3

Anfotericina B

Descripción:

Anfotericina B es un agente antifúngico polieno que se utiliza principalmente para tratar infecciones fúngicas graves, particularmente aquellas causadas por especies de Candida y Aspergillus. Se deriva de la bacteria Streptomyces nodosus y es conocido por su capacidad para unirse al ergosterol, un componente clave de las membranas celulares fúngicas, lo que lleva a la interrupción de la membrana celular y, en última instancia, a la muerte celular. Anfotericina B se caracteriza por su color marrón amarillento y se administra típicamente por vía intravenosa debido a su baja biodisponibilidad oral. Tiene un peso molecular relativamente alto y es soluble en dimetilsulfóxido (DMSO) y otros disolventes orgánicos, pero poco soluble en agua. El fármaco es conocido por sus posibles efectos secundarios, incluyendo nefrotoxicidad y reacciones relacionadas con la infusión, lo que requiere un monitoreo cuidadoso durante el tratamiento. Anfotericina B se utiliza a menudo en casos severos donde otros tratamientos antifúngicos pueden ser ineficaces, lo que lo convierte en una opción crítica en el manejo de infecciones fúngicas invasivas.

Fórmula: C₄₇H₇₃NO₁₇

InChI: InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

Clave InChI: InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N

SMILES: C(O)(=O)[C@H]1[C@]2(O[C@@](O)(C[C@@H]1O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C2)[H]

Sinónimos:

• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• Abelcet
• Abelecet
• AmBisome
• Ampho-Moronal
• Amphocin
• Amphozone
• Apothecon
• Fungilin
• Fungizona
• Fungizone
• Halizon
• Kalsome 10
• LNS-AmB
• Ns 718
• Nsc 527017
• amfotericina B
• amphotericine B
• Amphotericin B
• 17,37-octahydroxy-15,16,18-trimethyl-13-oxo-(1r-(1r*,3s*,5r*,6r*,9r*,11r*,15s*
• 14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carbo
• AMPHOTERICIN B, STREPTOMYCES NODOSUS
• AMPHOTERICIN B, STREPTOMYCES SPECIES
• FUNGIZONE(R)
• AMPHOTERCIN B
• amphotericineb
• AMPHOTERICIN B SOLUBILIZED
• 33-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,5,6,9,11,-xylicaci
• 33-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• AMPHOTERICIN B, SOLUBLE
• amphomoronal
• ,16r*,17r*,18s*,19e,21e,23e,25e-27e,29e,31e,33r*,35s*,36r*,37s*))-

Amphotericin B

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: >80.0%(HPLC)

Forma y color: White to Light orange to Yellow powder to crystal

Peso molecular: 924.09

Ref: 3B-A2114

Amphotericin B, 250 &mu;g/mL in distilled water, sterile-filtered

CAS: 1397-89-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67049

Amphotericin B, Streptomyces nodosus

CAS: 1397-89-3

Amphotericin B, Streptomyces nodosus, 1397-89-3, is a polyene with antibiotic properties which alters cell membrane permeability, leading to lysis and cell death. Learn more.

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.09

Ref: 02-J61491

AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1397-89-3

AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-Y0001361

AMPHOTERICIN B CRS

CAS: 1397-89-3

AMPHOTERICIN B CRS

Fórmula: C₄₇H₇₃NO₁₇

Forma y color: Added

Peso molecular: 924.079

Ref: 41-Y0000005

AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS

CAS: 1397-89-3

AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-Y0001014

AMPHOTERICIN B RS

CAS: 1397-89-3

AMPHOTERICIN B RS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-ICRS0210

SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B

CAS: 1397-89-3

SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-ISA_29078

Amphotericin B

CAS: 1397-89-3

Antibiotics nesoi

Fórmula: C₄₇H₇₃NO₁₇

Forma y color: Yellow Orange Powder

Peso molecular: 923.48785

Ref: 45-1032007

Amphotericin B

CAS: 1397-89-3

Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species.

Fórmula: C₄₇H₇₃NO₁₇

Pureza: 98% - ≥98%

Forma y color: Yellow Solid

Peso molecular: 924.079

Ref: TM-T1067

Amphotericin B

CAS: 1397-89-3

Amphotericin B

Fórmula: C₄₇H₇₃NO₁₇

Pureza: ≥98%

Forma y color: Solid

Peso molecular: 924.08

Ref: 54-BUP15128

Amphotericin B

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: ≥ 750μg/mg (C47H73NO17, dried basis)

Forma y color: Yellow to dark yellow or orange powder

Peso molecular: 924.10

Ref: 7W-GA8986

Amphotericin B, Ph. Eur. grade

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: ≤ 2.0% (at 383nm)

Forma y color: Yellow or orange powder

Peso molecular: 924.10

Ref: 7W-GA2492

Amphotericin B

CAS: 1397-89-3

Amphotericin B

Fórmula: C₄₇H₇₃NO₁₇

Forma y color: Solid-Powder

Peso molecular: 924.07902

Ref: 54-BIA0103

Amphotericin B

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Forma y color: Yellow Solid

Peso molecular: 924.09

Ref: 4Z-A-137002

Amphotericin B, USP grade

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Forma y color: Yellow to orange powder

Peso molecular: 924.10

Ref: 7W-GP6136

(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaen

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: 95%

Forma y color: Solid

Peso molecular: 924.0790

Ref: IN-DA00ILH6

Amphotericin B

Producto controlado

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Forma y color: Neat

Peso molecular: 924.08

Ref: 04-C10243050

Amphotericin B (85%)

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: 85%

Forma y color: Neat

Peso molecular: 924.08

Ref: TR-A634250

Amphotericin B-13C6

CAS: 1397-89-3

Fórmula: C₄₁₁₃C₆H₇₃NO₁₇

Peso molecular: 930.04

Ref: 4Z-A-137007