CAS 139893-43-9
:Sal de amonio de simvastatina
Descripción:
Sal de amonio de simvastatina es un derivado de la simvastatina, un medicamento ampliamente utilizado para reducir el colesterol que pertenece a la clase de las estatinas. Este compuesto se caracteriza por su capacidad para inhibir la HMG-CoA reductasa, una enzima crucial para la biosíntesis de colesterol en el hígado. Como sal de amonio, típicamente exhibe una mejor solubilidad en entornos acuosos en comparación con su compuesto original, lo que puede mejorar su biodisponibilidad y eficacia terapéutica. La estructura molecular incluye un anillo de lactona, que es esencial para su actividad biológica, y la presencia de un grupo de amonio contribuye a su naturaleza iónica. Sal de amonio de simvastatina se utiliza a menudo en formulaciones farmacéuticas, y su estabilidad, solubilidad y propiedades farmacocinéticas son críticas para su efectividad en el manejo de la hiperlipidemia. Además, puede presentar efectos secundarios comunes a las estatinas, como dolor muscular o alteraciones en las enzimas hepáticas, lo que requiere monitoreo durante el tratamiento. En general, Sal de amonio de simvastatina representa un compuesto importante en la gestión de la salud cardiovascular.
Fórmula:C25H40O6·H3N
InChI:InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);1H3/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
Clave InChI:InChIKey=FFPDWNBTEIXJJF-OKDJMAGBSA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@H](C[C@H](CC(O)=O)O)O)=C[C@H](C)C1)[H].N
Sinónimos:- (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate ammonium salt
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt (1:1), (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, [1S-[1α(βS*,δS*),2α,6β,8β,8aα]]-
- Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyheptanoate
- Ammonium simvastatin
- Simvastatin Ammouium Salt
- Simvastatin Hydroxy Acid, Ammonium Salt
- Simvastatin acid ammonium salt
- Simvastatin carboxylic acid ammonium salt
- Simvastatin hydroxyl acid ammonium salt
- Simvastatin impurity A
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Ammonium Tenivastatin
CAS:Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoiFórmula:C25H43NO6Forma y color:Off-White PowderPeso molecular:453.30904Simvastatin Ammonium Salt
CAS:Simvastatin Ammonium SaltFórmula:C25H43NO6Pureza:>98%Peso molecular:453.61Simvastatin acid ammonium
CAS:Simvastatin acid ammoniumFórmula:C25H43NO6Pureza:99.5%Peso molecular:453.62Simvastatin ammonium salt
CAS:Fórmula:C25H41NO5Pureza:≥ 95.0%Forma y color:White to light yellow, beige or light brown powderPeso molecular:435.60Simvastatin EP Impurity A Ammonium Salt (Simvastatin Acid Ammonium Salt, Tenivastatin Ammonium Salt)
CAS:Fórmula:C25H39O6·NH4Forma y color:Off-White SolidPeso molecular:435.58 18.04(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Ammonium Salt (Tenivastatin Ammonium Salt)
CAS:Producto controladoFórmula:C25H39O6·H4NForma y color:NeatPeso molecular:453.61Simvastatin-d6 Hydroxy Acid Ammonium Salt
CAS:Producto controladoApplications A deuterated metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),Fórmula:C25H37D6NO6Forma y color:NeatPeso molecular:459.65Simvastatin Hydroxy Acid Ammonium Salt
CAS:Applications A metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),Fórmula:C25H39O6·H4NForma y color:NeatPeso molecular:453.61Ammonium (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate
CAS:Ammonium (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoateFórmula:C25H43NO6Pureza:98%Peso molecular:453.61Simvastatin acid ammonium
CAS:Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.Fórmula:C25H43NO6Pureza:99.79%Forma y color:SolidPeso molecular:453.612Simvastatin hydroxy acid ammonium salt
CAS:Simvastatin is a hydrated, acylated statin that is used as a lipid-lowering drug. It inhibits HMG-CoA reductase, an enzyme that plays a central role in cholesterol biosynthesis. The reaction solution can be activated by mixing with an acyltransferase and the desired acyl group. Simvastatin has a toxicity profile that includes myopathy, rhabdomyolysis, and liver failure. Simvastatin also inhibits lipoprotein lipase and prevents the hydrolysis of triglycerides to fatty acids and glycerol. This leads to reduced levels of low-density lipoproteins (LDLs) and increased levels of high-density lipoproteins (HDLs). Simvastatin is converted into an amide form by enzymatic cleavage, which may lead to metabolic inhibition.Fórmula:C25H43NO6Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:453.61 g/mol
![(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaph…](https://static.cymitquimica.com/products/86/thumb/MM0158.13.jpg)
