CAS 1401031-39-7

6-Oxaspiro[4.5]decano-9-etanamina, N-[(3-metoxi-2-tienil)metil]-9-(2-piridinil)-, clorhidrato (1:1), (9R)-

Descripción:

6-Oxaspiro[4.5]decano-9-etanamina, N-[(3-metoxi-2-tienil)metil]-9-(2-piridinil)-, clorhidrato (1:1), (9R)- es un compuesto orgánico complejo caracterizado por su estructura espiracíclica, que incluye un sistema de anillos fusionados que contribuye a su única conformación tridimensional. La presencia de un moiety oxaspiro indica la incorporación de un átomo de oxígeno dentro del marco espiral, mejorando su reactividad química y su potencial actividad biológica. El compuesto presenta un grupo funcional etanamínico, lo que sugiere que puede exhibir propiedades relacionadas con las aminas, como la basicidad y la capacidad de formar enlaces de hidrógeno. Además, la presencia de un grupo tienilo y un grupo piridinilo indica interacciones potenciales con objetivos biológicos, lo que lo hace de interés en la química medicinal. La forma de sal clorhidrato mejora su solubilidad en entornos acuosos, lo que es beneficioso para aplicaciones farmacológicas. En general, la complejidad estructural de este compuesto y sus grupos funcionales sugieren que puede poseer propiedades farmacológicas interesantes, lo que justifica una mayor investigación en el desarrollo de fármacos y campos relacionados.

Fórmula: C₂₂H₃₀N₂O₂S·ClH

InChI: InChI=1S/C22H30N2O2S.ClH/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22;/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3;1H/t21-;/m1./s1

Clave InChI: InChIKey=YIIWXYLJZRISQP-ZMBIFBSDSA-N

SMILES: C(CNCC1=C(OC)C=CS1)[C@@]2(CC3(OCC2)CCCC3)C4=CC=CC=N4.Cl

Sinónimos:

• (9R)-N-[(3-Methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-6-oxaspiro[4.5]decane-9-ethanamine hydrochloride (1:1)
• 6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)-

TRV-130 Hydrochloric Acid Salt

CAS: 1401031-39-7

Fórmula: C₂₂H₃₀N₂O₂S·HCl

Ref: TR-TRC-T895530

TRV-130 Hydrochloric Acid Salt

Producto controlado

CAS: 1401031-39-7

Applications TRV-130 is a μ-opioid receptor (MOR) G protein-biased ligand. It is potently analgesic while causing less gastrointestinal dysfunction and respiratory suppression than morphine at equianalgesic doses.
References DeWire, S., et al.: J. Pharm. Exper. Ther., 344, 708 (2013); Soergel, D., et al.: Pain, 155, 1829 (2014)

Fórmula: C₂₂H₃₀N₂O₂S·HCl

Forma y color: Neat

Peso molecular: 423.01

Ref: TR-T895530

TRV-130·HCl

Producto controlado

CAS: 1401031-39-7

TRV-130·HCl is a mu-opioid receptor agonist that has been shown to produce antinociceptive effects in both acute and chronic pain models. It has also been shown to have potential therapeutic benefits in animal models of neuropathic pain, inflammatory pain, and visceral pain. TRV-130·HCl has a high binding affinity for the mu-opioid receptor and can be used as an analgesic drug candidate. This compound produces a profile that is similar to morphine, although it may lack some of the side effects common with this drug. TRV-130·HCl has not yet undergone any clinical trials for human use and there is no information on its safety or efficacy during pregnancy.

Fórmula: C₂₂H₃₀N₂O₂S·HCl

Pureza: Min. 95%

Peso molecular: 423.01 g/mol

Ref: 3D-FT137730

TRV-130·HCl (racemic, 95%+)

Producto controlado

CAS: 1401031-39-7

TRV-130 is a mu-opioid agonist with nociceptive and antinociceptive properties. It has been shown to have a high affinity for the mu-opioid receptor, which is responsible for pain control. TRV-130 has also been found to be effective against inflammatory pain and neuropathic pain in animal models. TRV-130 has been shown to decrease the release of glutamate and substance P in animal models, which are neurotransmitters that play an important role in inflammatory and neuropathic pain. TRV-130 may also be used as a therapeutic strategy for the treatment of chronic pain.

Fórmula: C₂₂H₃₀N₂O₂S·HCl

Pureza: Min. 95%

Peso molecular: 423.01 g/mol

Ref: 3D-FT137731

6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)-

CAS: 1401031-39-7

Fórmula: C₂₂H₃₁ClN₂O₂S

Forma y color: Solid

Peso molecular: 423.0117

Ref: IN-DA001C0F