CAS 142880-36-2

Ilomastat

Descripción:

Ilomastat, también conocido por su nombre químico, es un compuesto sintético clasificado como un inhibidor de metaloproteinasas de matriz (MMP). Se investiga principalmente por sus posibles aplicaciones terapéuticas en el tratamiento de diversas enfermedades, incluyendo el cáncer y condiciones fibróticas. La sustancia actúa inhibiendo la actividad de las MMP, que son enzimas involucradas en la degradación de los componentes de la matriz extracelular, influyendo así en los procesos de remodelación y reparación de tejidos. Ilomastat ha sido estudiado por su capacidad para reducir la invasión tumoral y la metástasis al limitar la descomposición de la matriz extracelular. En términos de sus propiedades físicas, Ilomastat se caracteriza típicamente por su estructura molecular específica, que incluye grupos funcionales que contribuyen a su actividad biológica. El compuesto se administra generalmente de manera controlada en entornos clínicos, y su farmacocinética, incluyendo absorción, distribución, metabolismo y excreción, son críticas para entender su eficacia y perfil de seguridad. La investigación en curso continúa explorando su potencial completo y mecanismos de acción en diversos contextos terapéuticos.

Fórmula: C₂₀H₂₈N₄O₄

InChI: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

Clave InChI: InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N

SMILES: C([C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C(NC)=O)C=1C=2C(NC1)=CC=CC2

Sinónimos:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• (2R)-N~4~-hydroxy-N~1~-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
• (R)-N1-((S)-3-(1H-indol-3yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-Indol-3-Yl)-1-Methylcarbamoly-Ethyl]-2-Isobutyl-Succinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-
• Cs 610
• Galardin
• Galardin Tm
• Galardin, GM6001, Ilomastat
• Gm 6001
• Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

Illomastat

CAS: 142880-36-2

Fórmula: C₂₀H₂₈N₄O₄

Pureza: 95%

Forma y color: Solid

Peso molecular: 388.4607

Ref: IN-DA00350G

Ilomastat

CAS: 142880-36-2

Ilomastat

Fórmula: C₂₀H₂₈N₄O₄

Pureza: ≥95%

Peso molecular: 388.46

Ref: 54-BUP12328

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

CAS: 142880-36-2

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

Fórmula: C₂₀H₂₈N₄O₄

Pureza: 98%

Peso molecular: 388.46

Ref: 54-OR1023104

Ilomastat

CAS: 142880-36-2

Fórmula: C₂₀H₂₈N₄O₄

Pureza: >95.0%(HPLC)(qNMR)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 388.47

Ref: 3B-I1202

Ilomastat

CAS: 142880-36-2

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

Fórmula: C₂₀H₂₈N₄O₄

Pureza: 98%

Peso molecular: 388.46

Ref: IN-DG134339

Ilomastat

CAS: 142880-36-2

Fórmula: C₂₀H₂₈N₄O₄

Peso molecular: 388.50

Ref: 7W-GK4753

Ilomastat

CAS: 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Fórmula: C₂₀H₂₈N₄O₄

Pureza: 97.04% - 99.51%

Forma y color: White Solid

Peso molecular: 388.46

Ref: TM-T2743

Ilomastat

Producto controlado

CAS: 142880-36-2

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Fórmula: C₂₀H₂₈N₄O₄

Forma y color: Neat

Peso molecular: 388.46

Ref: TR-I267180

Galardinᵀᴹ

CAS: 142880-36-2

Galardinâ„¢ is an experimental drug with inhibitory properties, which can be used as a potential drug target to treat various diseases. It inhibits the polymerase chain reaction by binding to the enzyme DNA polymerase and preventing its activity. Galardinâ„¢ also has been shown to have protective effects against oxidative injury in 3T3-L1 preadipocytes and protect cells from cell death by inhibiting toll-like receptor signaling pathways. In addition, it has antimicrobial activity against Candida glabrata and other bacterial strains, such as Staphylococcus aureus and Acinetobacter baumannii.

Fórmula: C₂₀H₂₈N₄O₄

Pureza: Min. 95%

Peso molecular: 388.47 g/mol

Ref: 3D-INH-3927-PI

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

CAS: 142880-36-2

Pureza: 95%+

Peso molecular: 388.4679871

Ref: 10-F868898

GM 6001

CAS: 142880-36-2

GM 6001 is a matrix that contains benzalkonium chloride. It is used as a pharmacological agent to prevent the growth of bacteria, fungi, and viruses. This product inhibits the synthesis of proteins that are required for cell division and may cause neuronal death. GM 6001 has been shown to inhibit the expression of matrix metalloproteinase-9 (MMP-9) in cultured cells, which may be due to its interference with the synthesis of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α). GM 6001 also has potent immunosuppressive properties by inhibiting toll-like receptors (TLRs) in macrophages and dendritic cells. The TLRs are important for initiating immune responses against pathogens.

Fórmula: C₂₀H₂₈N₄O₄

Pureza: Min. 95%

Peso molecular: 388.46 g/mol

Ref: 3D-SFA88036