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CAS 1460272-53-0

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Fórmula:C24H23FN4O4
InChI:InChI=1S/C24H23FN4O4/c25-19-8-7-15(21(30)20-16-3-1-2-4-17(16)22(31)27-26-20)13-18(19)24(33)29-11-9-28(10-12-29)23(32)14-5-6-14/h1-4,7-8,13-14,21,30H,5-6,9-12H2,(H,27,31)
Clave InChI:ZXEUVLDIXBFJCR-UHFFFAOYSA-N
SMILES:C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)C(C4=NNC(=O)C5=CC=CC=C54)O)F
Se han encontrado 2 productos.
  • Olaparib Impurity 86
    TLC
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    Olaparib Impurity 86

    CAS:
    Fórmula:C24H23FN4O4
    Peso molecular:450.47

    Ref: 4Z-O-032097

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    25mg
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  • 4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(…
    TRC
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    4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one

    Producto controlado
    CAS:

    Applications 4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one is an impurity of Olaparib (O514500), a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor.
    References Weston, V.J. et al.: Blood, 116, 4578 (2010); Senra, J.M. et al.: Mol. Cancer Therap., 10, 1949 (2011); Schaefer, N.G. et al.: Nuc. Med. Comm., 32, 1046 (2011);

    Fórmula:C24H23FN4O4
    Forma y color:Neat
    Peso molecular:450.46

    Ref: TR-C992278

    25mg
    1.722,00€