CAS 147127-20-6
:Tenofovir
Descripción:
Tenofovir es un medicamento antirretroviral que se utiliza principalmente en el tratamiento y prevención del VIH/SIDA y la hepatitis B crónica. Pertenece a la clase de inhibidores de la transcriptasa inversa de nucleótidos (NRTIs) y funciona inhibiendo la enzima transcriptasa inversa, que es crucial para la replicación viral. La estructura química de Tenofovir incluye un grupo fosfonato, que contribuye a su mecanismo de acción. Se administra típicamente en forma de su sal de fumarato de disoproxilo, lo que mejora su biodisponibilidad. Tenofovir es conocido por su perfil de seguridad relativamente favorable, aunque puede estar asociado con toxicidad renal y pérdida de densidad mineral ósea en algunos pacientes. La sustancia es soluble en agua, lo que facilita su formulación en formas de dosificación oral. Su farmacocinética implica una rápida absorción y conversión a su forma activa, Tenofovir difosfato, dentro de las células. Como un componente clave de las terapias combinadas, Tenofovir desempeña un papel significativo en el manejo de la infección por VIH y también se utiliza en la profilaxis previa a la exposición (PrEP) para reducir el riesgo de transmisión del VIH.
Fórmula:C9H14N5O4P
InChI:InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
Clave InChI:InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N
SMILES:C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2
Sinónimos:- P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
- Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
- (R)-9-(2-Phosphonomethoxypropyl)adenine
- Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
- Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-
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Encontrado 15 productos.
Tenofovir
CAS:Fórmula:C9H14N5O4PPureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalinePeso molecular:287.22Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
CAS:Fórmula:C9H14N5O4PPureza:95%Forma y color:SolidPeso molecular:287.2123Tenofovir
CAS:<p>Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.</p>Fórmula:C9H14N5O4PPureza:98.69% - 99.92%Forma y color:White To Tan Solid Solid PowderPeso molecular:287.21Tenofovir
CAS:Fórmula:C9H14N5O4PPureza:≥ 98.0% (anhydrous)Forma y color:White to off-white powderPeso molecular:287.21Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C9H14N5O4PForma y color:White To Off-WhitePeso molecular:287.21Tenofovir - Bio-X ™
CAS:<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. <br>Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C9H14N5O4PPureza:Min. 98.5 Area-%Forma y color:White To Off-White SolidPeso molecular:287.21 g/molTenofovir
CAS:<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.</p>Fórmula:C9H14N5O4PPureza:Min. 95%Forma y color:White Clear LiquidPeso molecular:287.21 g/mol(R)-9-(2-Phosphonomethoxypropyl)adenine
CAS:Fórmula:C9H14N5O4PPureza:95%Forma y color:SolidPeso molecular:287.216Tenofovir (1 mg/mL in Water)
CAS:Fórmula:C9H14N5O4PForma y color:Single SolutionPeso molecular:287.21Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)
CAS:Producto controlado<p>Impurity Tenofovir Impurity<br>Stability Light Sensitive<br>Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.<br>References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C18H29N6O9PForma y color:NeatPeso molecular:504.431
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