CAS 147127-20-6

Tenofovir

Descripción:

Tenofovir es un medicamento antirretroviral que se utiliza principalmente en el tratamiento y prevención del VIH/SIDA y la hepatitis B crónica. Pertenece a la clase de inhibidores de la transcriptasa inversa de nucleótidos (NRTIs) y funciona inhibiendo la enzima transcriptasa inversa, que es crucial para la replicación viral. La estructura química de Tenofovir incluye un grupo fosfonato, que contribuye a su mecanismo de acción. Se administra típicamente en forma de su sal de fumarato de disoproxilo, lo que mejora su biodisponibilidad. Tenofovir es conocido por su perfil de seguridad relativamente favorable, aunque puede estar asociado con toxicidad renal y pérdida de densidad mineral ósea en algunos pacientes. La sustancia es soluble en agua, lo que facilita su formulación en formas de dosificación oral. Su farmacocinética implica una rápida absorción y conversión a su forma activa, Tenofovir difosfato, dentro de las células. Como un componente clave de las terapias combinadas, Tenofovir desempeña un papel significativo en el manejo de la infección por VIH y también se utiliza en la profilaxis previa a la exposición (PrEP) para reducir el riesgo de transmisión del VIH.

Fórmula: C₉H₁₄N₅O₄P

InChI: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

Clave InChI: InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES: C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2

Sinónimos:

• P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
• Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• (R)-9-(2-Phosphonomethoxypropyl)adenine
• Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: >98.0%(HPLC)(T)

Forma y color: White to Almost white powder to crystaline

Peso molecular: 287.22

Ref: 3B-T3006

Tenofovir

CAS: 147127-20-6

Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.

Fórmula: C₉H₁₄N₅O₄P

Pureza: 98.69% - 99.92%

Forma y color: White To Tan Solid Solid Powder

Peso molecular: 287.21

Ref: TM-T1649

Tenofovir

CAS: 147127-20-6

Tenofovir

Fórmula: C₉H₁₄N₅O₄P

Pureza: >98%

Peso molecular: 287.21

Ref: 54-OR1030259

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Forma y color: White To Off-White Solid

Peso molecular: 287.22

Ref: 4Z-T-023

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: ≥ 98.0% (anhydrous)

Forma y color: White to off-white powder

Peso molecular: 287.21

Ref: 7W-GP5400

Tenofovir

CAS: 147127-20-6

Tenofovir

Fórmula: C₉H₁₄N₅O₄P

Pureza: 99.5%

Peso molecular: 287.21

Ref: 54-BUP16961

Tenofovir

Producto controlado

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Forma y color: Neat

Peso molecular: 287.21

Ref: 86-MM1329.19-0025

(R)-9-(2-Phosphonomethoxypropyl)adenine

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: 95%

Forma y color: Solid

Peso molecular: 287.2123

Ref: IN-DA001EMI

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Forma y color: Neat

Peso molecular: 287.21

Ref: 86-MM1329.19

Tenofovir (Standard)

CAS: 147127-20-6

Tenofovir (Standard) is a reference standard for research and analysis in studies involving Tenofovir. Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

Fórmula: C₉H₁₄N₅O₄P

Peso molecular: 287.21

Ref: TM-TMSM-3394

Tenofovir (1 mg/mL in Water)

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Forma y color: Single Solution

Peso molecular: 287.21

Ref: TR-KIT7765

Tenofovir

CAS: 147127-20-6

Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Fórmula: C₉H₁₄N₅O₄P

Forma y color: Neat

Peso molecular: 287.21

Ref: TR-T018500

Tenofovir

CAS: 147127-20-6

(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid

Fórmula: C₉H₁₄N₅O₄P

Pureza: 95%

Peso molecular: 287.21

Ref: IN-DG18435

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Peso molecular: 287.21

Ref: ST-EA-CP-T5000

Tenofovir - Bio-X ™

CAS: 147127-20-6

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. 
Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₉H₁₄N₅O₄P

Pureza: Min. 98.5 Area-%

Forma y color: White To Off-White Solid

Peso molecular: 287.21 g/mol

Ref: 3D-BT164455

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Forma y color: Solid

Peso molecular: 287.21

Ref: BE-MU-7104

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Forma y color: Solid

Peso molecular: 287.21

Ref: BE-RMCT081000

(R)-9-(2-Phosphonomethoxypropyl)adenine

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: 95%

Forma y color: Solid

Peso molecular: 287.216

Ref: 10-F077792

Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)

Producto controlado

CAS: 147127-20-6

Impurity Tenofovir Impurity
Stability Light Sensitive
Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.
References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Fórmula: C₁₈H₂₉N₆O₉P

Forma y color: Neat

Peso molecular: 504.431

Ref: TR-M540865

Tenofovir (1.0 mg/mL in Water)

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Ref: TR-KIT7765-1ML