CAS 1476-53-5

Novobiocina sódica

Descripción:

Novobiocina sódica, con el número CAS 1476-53-5, es un compuesto antibiótico que pertenece a la clase de derivados de cumarina. Se deriva principalmente de la bacteria *Streptomyces niveus* y exhibe propiedades antibacterianas, particularmente contra bacterias Gram-positivas. La novobiocina funciona inhibiendo la girasa del ADN bacteriano, una enzima crítica para la replicación y transcripción del ADN, interrumpiendo así el crecimiento bacteriano. La forma de sal sódica mejora su solubilidad en soluciones acuosas, lo que la hace adecuada para diversas aplicaciones farmacéuticas. Además de su actividad antibacteriana, se ha estudiado la novobiocina por su posible uso en terapia contra el cáncer debido a su capacidad para inhibir ciertos procesos celulares. El compuesto se administra típicamente en un entorno clínico y está sujeto a pautas de dosificación específicas debido a sus efectos farmacológicos. Los perfiles de seguridad y eficacia son consideraciones esenciales en su uso, al igual que con cualquier antibiótico, para prevenir el desarrollo de resistencia y garantizar resultados terapéuticos óptimos.

Fórmula: C₃₁H₃₆N₂O₁₁·Na

InChI: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/t23-,25+,26-,29-;/m1./s1

Clave InChI: InChIKey=BZFOBLOAMAJKQV-RNROJPEYSA-N

SMILES: CC1=C2C(C(O)=C(NC(=O)C3=CC(CC=C(C)C)=C(O)C=C3)C(=O)O2)=CC=C1O[C@H]4[C@H](O)[C@H](OC(N)=O)[C@@H](OC)C(C)(C)O4.[Na]

Sinónimos:

• (3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• 5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• Albamycin
• Albamycin (capsule)
• Albamycin sodium
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-, sodium salt (1:1)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
• Cathomycin sodium
• Cathomycin sodium lyovac
• Monosodium novobiocin
• N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
• NSC 2382
• Novobiocin Sodium
• Novobiocin Sodium Crystalline
• Novobiocin Sodium Usp
• Novobiocin monosodium
• Novobiocin, monosodium salt
• Novobiocin, sodium deriv.
• Sodium albamycin
• Sodium novobiocin
• Vulcamycin
• sodium 7-{[(2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-4-olate (non-preferred name)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt, 1476-53-5, is an antibiotic compound produced by Streptomyces nieveus which inhibits topoisomerase II. Learn more at Thermo Fisher Scientific.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Forma y color: White to pale cream to yellow, Powder

Peso molecular: 634.61

Ref: 02-J60928

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt

Fórmula: C₃₁H₃₅N₂O₁₁·Na

Pureza: By hplc: 96.2% by area (Typical Value in Batch COA)

Forma y color: Solid-Powder

Peso molecular: 634.60617

Ref: 54-BIN0394

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: ≥98%

Peso molecular: 634.614

Ref: 54-BUP11826

Novobiocin sodium

CAS: 1476-53-5

Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: 95%

Peso molecular: 634.61

Ref: IN-DG145504

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: 99% - 99.51%

Forma y color: Solid

Peso molecular: 634.61

Ref: TM-T0974

Novobiocin Sodium Salt

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: 95%

Forma y color: Solid

Peso molecular: 634.6062

Ref: IN-DA00AOT3

Novobiocin sodium salt, USP grade

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: ≥ 90.0%

Forma y color: White to off-white powder

Peso molecular: 634.61

Ref: 7W-GP5629

Novobiocin sodium salt

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: ≥ 95.0% (dried basis)

Forma y color: White to off-white powder

Peso molecular: 634.61

Ref: 7W-GA5711

Novobiocin Sodium (Standard)

CAS: 1476-53-5

Novobiocin Sodium (Standard) is the standard substance of Novobiocin Sodium, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Forma y color: Solid

Peso molecular: 634.61

Ref: TM-TMSM-1779

Novobiocin sodium

Producto controlado

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂O₁₁·Na

Forma y color: Neat

Peso molecular: 634.61

Ref: 04-C15654200

Novobiocin Sodium Salt

Producto controlado

CAS: 1476-53-5

Stability Hygroscopic
Applications Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
References Cozarelli, N.R.: Science, 207, 953 (1980); Sumiyoshi, Y. et al.: J. Gen. Virol., 64, 2329 (1983); Lockshon, G. et al.: Nucleic Acids Res., 11, 2999 (1983);

Fórmula: C₃₁H₃₅N₂O₁₁·Na

Forma y color: Neat

Peso molecular: 634.61

Ref: TR-N888500

Novobiocin sodium salt, Antibiotic for Culture Media Use Only

CAS: 1476-53-5

Novobiocin sodium salt inhibits bacterial growth by binding to the 50S subunit of the bacterial ribosome, blocking the peptidyl transferase activity required for protein synthesis. The drug binds to DNA sequences containing glucuronic acid, which are essential for peptide bond formation. Novobiocin sodium can be found in pharmaceuticals due to its antimicrobial activity and membrane stability, which makes it suitable for pressuring ionization techniques. It also exhibits less resistance than other antibiotics like triclosan or nalidixic acid because it does not typically bind to the membranes of cells.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: Min. 90.0 Area-%

Peso molecular: 634.61 g/mol

Ref: 3D-N-9100

Novobiocin sodium

CAS: 1476-53-5

Inhibitor of prokaryotic DNA gyrase, eukaryotic DNA topoisomerase and HSP90

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: Min. 94%

Forma y color: Powder

Peso molecular: 634.61 g/mol

Ref: 3D-EN15775

Novobiocin Sodium Salt (NVB), 95%

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: min. 95%

Forma y color: White to pale yellow, Powder, Clear

Peso molecular: 634.61

Ref: SR-27434

Novobiocin Sodium

CAS: 1476-53-5

Fórmula: C₃₁H₃₆N₂O₁₁Na

Peso molecular: 612.63 : 22.99

Ref: ST-EA-CP-N101001