CAS 150683-30-0
:Tolvaptán
Descripción:
Tolvaptán es un antagonista selectivo del receptor V2 de vasopresina que se utiliza principalmente en el tratamiento de condiciones como la hiponatremia y la enfermedad renal poliquística autosómica dominante (ADPKD). Es una pequeña molécula orgánica caracterizada por su capacidad para inhibir la acción de la vasopresina, una hormona que regula la retención de agua en los riñones. Esta inhibición conduce a un aumento en la producción de orina y a un posterior aumento en los niveles de sodio en suero. Tolvaptán se administra típicamente por vía oral y es conocido por su relativamente alta biodisponibilidad. La sustancia se clasifica como un antagonista no péptido y tiene una estructura molecular específica que contribuye a sus propiedades farmacológicas. Los efectos secundarios comunes pueden incluir sed, boca seca y posibles anomalías en la función hepática, lo que requiere un monitoreo regular durante el tratamiento. Debido a su mecanismo de acción, Tolvaptán es particularmente beneficioso en el manejo de condiciones de sobrecarga de líquidos, lo que lo convierte en un agente terapéutico valioso en nefrología y endocrinología.
Fórmula:C26H25ClN2O3
InChI:InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
Clave InChI:InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(=CC(Cl)=CC2)C(O)CCC1)C3=C(C)C=C(NC(=O)C4=C(C)C=CC=C4)C=C3
Sinónimos:- 1-[4-(2-Methylbenzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol
- 1H-1-Benzazepine, benzamide deriv.
- Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-
- Jinarc
- Jynarque
- N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide
- N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide
- N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide
- N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
- N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
- Opc 41061
- Samsca
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Encontrado 11 productos.
Tolvaptan
CAS:Fórmula:C26H25ClN2O3Pureza:≥ 98.0%Forma y color:White to off-white powderPeso molecular:448.94Tolvaptan
CAS:<p>Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.</p>Fórmula:C26H25ClN2O3Pureza:99.78% - >99.99%Forma y color:SolidPeso molecular:448.94N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:448.95001220703125Tolvaptan
CAS:Producto controlado<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>Fórmula:C26H25ClN2O3Forma y color:White To Off-WhitePeso molecular:448.94Tolvaptan - Bio-X ™
CAS:Producto controlado<p>Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.</p>Fórmula:C26H25ClN2O3Pureza:Min. 95%Forma y color:PowderPeso molecular:448.94 g/molTolvaptan
CAS:Producto controlado<p>Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.</p>Fórmula:C26H25ClN2O3Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:448.94 g/molTolvaptan
CAS:Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFórmula:C26H25ClN2O3Forma y color:White PowderPeso molecular:448.15537Ref: IN-DA00366Q
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