CAS 150683-30-0

Tolvaptán

Descripción:

Tolvaptán es un antagonista selectivo del receptor V2 de vasopresina que se utiliza principalmente en el tratamiento de condiciones como la hiponatremia y la enfermedad renal poliquística autosómica dominante (ADPKD). Es una pequeña molécula orgánica caracterizada por su capacidad para inhibir la acción de la vasopresina, una hormona que regula la retención de agua en los riñones. Esta inhibición conduce a un aumento en la producción de orina y a un posterior aumento en los niveles de sodio en suero. Tolvaptán se administra típicamente por vía oral y es conocido por su relativamente alta biodisponibilidad. La sustancia se clasifica como un antagonista no péptido y tiene una estructura molecular específica que contribuye a sus propiedades farmacológicas. Los efectos secundarios comunes pueden incluir sed, boca seca y posibles anomalías en la función hepática, lo que requiere un monitoreo regular durante el tratamiento. Debido a su mecanismo de acción, Tolvaptán es particularmente beneficioso en el manejo de condiciones de sobrecarga de líquidos, lo que lo convierte en un agente terapéutico valioso en nefrología y endocrinología.

Fórmula: C₂₆H₂₅ClN₂O₃

InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

Clave InChI: InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(=CC(Cl)=CC2)C(O)CCC1)C3=C(C)C=C(NC(=O)C4=C(C)C=CC=C4)C=C3

Sinónimos:

• 1-[4-(2-Methylbenzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol
• 1H-1-Benzazepine, benzamide deriv.
• Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-
• Jinarc
• Jynarque
• N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide
• N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide
• N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide
• N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
• N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
• Opc 41061
• Samsca

Tolvaptan

CAS: 150683-30-0

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Fórmula: C₂₆H₂₅ClN₂O₃

Forma y color: White Powder

Peso molecular: 448.15537

Ref: 45-1672060

Tolvaptan

CAS: 150683-30-0

Fórmula: C₂₆H₂₅ClN₂O₃

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 448.94

Ref: 7W-GP7013

Tolvaptan

CAS: 150683-30-0

Fórmula: C₂₆H₂₅ClN₂O₃

Forma y color: White To Off-White Solid

Peso molecular: 448.95

Ref: 4Z-T-691

Tolvaptan

Producto controlado

CAS: 150683-30-0

Fórmula: C₂₆H₂₅ClN₂O₃

Forma y color: Neat

Peso molecular: 448.94

Ref: 86-MM3561.00

Tolvaptan

Producto controlado

CAS: 150683-30-0

Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);

Fórmula: C₂₆H₂₅ClN₂O₃

Forma y color: Neat

Peso molecular: 448.94

Ref: TR-T536650

Tolvaptan

CAS: 150683-30-0

Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.

Fórmula: C₂₆H₂₅ClN₂O₃

Pureza: 99.78% - >99.99%

Forma y color: Solid

Peso molecular: 448.94

Ref: TM-T2326

Tolvaptan RS

CAS: 150683-30-0

Forma y color: White Crystals Or Crystalline Powder

Ref: 2K-109810002

Tolvaptan

CAS: 150683-30-0

Fórmula: C₂₆H₂₅ClN₂O₃

Peso molecular: 448.95

Ref: ST-EA-CP-T26000

N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

CAS: 150683-30-0

Pureza: 95.0%

Forma y color: Solid

Peso molecular: 448.95001220703125

Ref: 10-F361970

Tolvaptan

Producto controlado

CAS: 150683-30-0

Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.

Fórmula: C₂₆H₂₅ClN₂O₃

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 448.94 g/mol

Ref: 3D-FT34175

Tolvaptan - Bio-X ™

Producto controlado

CAS: 150683-30-0

Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.

Fórmula: C₂₆H₂₅ClN₂O₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 448.94 g/mol

Ref: 3D-BT164486

Tolvaptan RS

CAS: 150683-30-0

Forma y color: White Crystals Or Crystalline Powder

Ref: 2K-1098100021