CAS 152520-56-4
:Clorhidrato de nebivolol
Descripción:
Clorhidrato de nebivolol es un bloqueador selectivo de los receptores adrenérgicos beta-1 que se utiliza principalmente en el tratamiento de la hipertensión y la insuficiencia cardíaca. Se caracteriza por su capacidad para reducir la presión arterial al disminuir la frecuencia cardíaca y la contractilidad miocárdica, lo que a su vez disminuye el gasto cardíaco. El nebivolol es único entre los beta-bloqueadores debido a sus propiedades vasodilatadoras, que se atribuyen a su capacidad para estimular la liberación de óxido nítrico, lo que conduce a una mejor función endotelial. La sustancia se administra típicamente por vía oral y se absorbe bien, con un perfil farmacocinético favorable que incluye una larga vida media, lo que permite una dosificación una vez al día. Clorhidrato de nebivolol generalmente es bien tolerado, con un perfil de efectos secundarios que puede incluir dolor de cabeza, fatiga y trastornos gastrointestinales. Su estructura química incluye un centro quiral, lo que resulta en diferentes efectos farmacológicos entre sus enantiómeros. En general, Clorhidrato de nebivolol representa un enfoque moderno para el manejo de condiciones cardiovasculares, combinando eficacia con un perfil de seguridad relativamente favorable.
Fórmula:C22H25F2NO4·ClH
InChI:InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/s2
Clave InChI:InChIKey=JWEXHQAEWHKGCW-NJEBDULONA-N
SMILES:[C@@H](CNC[C@H](O)[C@]1(OC=2C(CC1)=CC(F)=CC2)[H])(O)[C@@]3(OC=4C(CC3)=CC(F)=CC4)[H].Cl
Sinónimos:- 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] hydrochloride
- 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
- 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, (αR,α′R,2R,2′S)-rel-
- 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-
- Lobivon
- Nebicard
- Nebilet
- Nebilox
- Nebivolol hcl
- Nebivololhydrochloride(Subjecttopatentfree)
- Nodon
- R 067555
- R-67555
- Rac Nebivolol, Hydrochloride
- a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
- a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
- NEBIVOLOL HC
- Nebivolol (Bystolic)
- alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
- D06622
- a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
- Nebivolol hydrochloride (usan)
- Nebivolol hydrochloride, >=98%
- (aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
- (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
- rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
- Nebivolol hydrochloride
- Bystolic
- Narbivolol
- Ver más sinónimos
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Encontrado 16 productos.
Nebivolol Hydrochloride
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFórmula:C22H25F2NO4·HClForma y color:White Off-White PowderPeso molecular:441.15184Nebivolol Hydrochloride
CAS:Fórmula:C22H26ClF2NO4Pureza:97%Forma y color:SolidPeso molecular:441.8959Nebivolol hydrochloride
CAS:<p>Nebivolol hydrochloride is a beta-1 blocker and vasodilator treating hypertension and heart failure in the elderly.</p>Fórmula:C22H25F2NO4·HClPureza:99.77% - >99.99%Forma y color:White To Off-White PowderPeso molecular:441.90Nebivolol hydrochloride
CAS:Fórmula:C22H25F2NO4·HClPureza:≥ 98.0% (anhydrous basis)Forma y color:White to off-white crystalline powderPeso molecular:441.90Nebivolol HCl
CAS:Fórmula:C22H25F2NO4·HClForma y color:White To Off-White SolidPeso molecular:405.45 36.46Nebivolol Hydrochloride
CAS:Producto controladoFórmula:C22H25F2NO4·ClHForma y color:NeatPeso molecular:441.90Nebivolol Hydrochloride
CAS:Fórmula:C22H25F2NO4·HClPureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:441.90Nebivolol Hydrochloride
CAS:<p>Applications Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990);<br></p>Fórmula:C22H25F2NO4·ClHForma y color:WhitePeso molecular:441.90Nebivolol HCl - Bio-X ™
CAS:Producto controlado<p>Nebivolol is a beta-blocker that is used to treat high blood pressure. It is also used in the treatment of angina, to decrease the heart rate and contractile force. Nebivolol has weak beta-2 adrenergic receptor antagonist action but is a highly selective beta-1 adrenergic receptor antagonist. Nebivolol's ability to block beta-1 adrenergic receptors results in a reduction in myocardial contractility, systolic and diastolic blood pressure, resting heart rate, and workout heart rate.</p>Fórmula:C22H25F2NO4·HClPureza:(%) Min. 95%Forma y color:White/Off-White SolidPeso molecular:441.9 g/molNebivolol hydrochloride
CAS:Producto controladoNebivolol HCl is a beta-blocker that is used to treat high blood pressure and heart failure. It is a prodrug that is metabolized in vivo to its active form, nebivolol. Nebivolol HCl has a low bioavailability of about 5%, which may be due to the presence of excipients or the formation of solid dispersions with other ingredients in the formulation. Nebivolol HCl also interacts with many drugs that are metabolized by CYP2D6, CYP3A4, and CYP1A2 enzymes, such as metoprolol succinate, sodium citrate, and hydrochloric acid. This drug also has an adverse effect on geriatric patients because it can cause dizziness due to orthostatic hypotension.Fórmula:C22H25F2NO4•HClPureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:441.9 g/mol
