CAS 152520-56-4

Clorhidrato de nebivolol

Descripción:

Clorhidrato de nebivolol es un bloqueador selectivo de los receptores adrenérgicos beta-1 que se utiliza principalmente en el tratamiento de la hipertensión y la insuficiencia cardíaca. Se caracteriza por su capacidad para reducir la presión arterial al disminuir la frecuencia cardíaca y la contractilidad miocárdica, lo que a su vez disminuye el gasto cardíaco. El nebivolol es único entre los beta-bloqueadores debido a sus propiedades vasodilatadoras, que se atribuyen a su capacidad para estimular la liberación de óxido nítrico, lo que conduce a una mejor función endotelial. La sustancia se administra típicamente por vía oral y se absorbe bien, con un perfil farmacocinético favorable que incluye una larga vida media, lo que permite una dosificación una vez al día. Clorhidrato de nebivolol generalmente es bien tolerado, con un perfil de efectos secundarios que puede incluir dolor de cabeza, fatiga y trastornos gastrointestinales. Su estructura química incluye un centro quiral, lo que resulta en diferentes efectos farmacológicos entre sus enantiómeros. En general, Clorhidrato de nebivolol representa un enfoque moderno para el manejo de condiciones cardiovasculares, combinando eficacia con un perfil de seguridad relativamente favorable.

Fórmula: C₂₂H₂₅F₂NO₄·ClH

InChI: InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/s2

Clave InChI: InChIKey=JWEXHQAEWHKGCW-NJEBDULONA-N

SMILES: [C@@H](CNC[C@H](O)[C@]1(OC=2C(CC1)=CC(F)=CC2)[H])(O)[C@@]3(OC=4C(CC3)=CC(F)=CC4)[H].Cl

Sinónimos:

• 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] hydrochloride
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-
• Lobivon
• Nebicard
• Nebilet
• Nebilox
• Nebivolol hcl
• Nebivololhydrochloride(Subjecttopatentfree)
• Nodon
• R 067555
• R-67555
• Rac Nebivolol, Hydrochloride
• a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
• NEBIVOLOL HC
• Nebivolol (Bystolic)
• alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• D06622
• a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• Nebivolol hydrochloride (usan)
• Nebivolol hydrochloride, >=98%
• (aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
• rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
• Nebivolol hydrochloride
• Bystolic
• Narbivolol

Nebivolol Hydrochloride

CAS: 152520-56-4

Forma y color: Neat

Ref: 61-FOR0947.00

NEBIVOLOL FOR PEAK IDENTIFICATION CRS

CAS: 152520-56-4

NEBIVOLOL FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002306

NEBIVOLOL HYDROCHLORIDE CRS

CAS: 152520-56-4

NEBIVOLOL HYDROCHLORIDE CRS

Forma y color: Added

Ref: 41-Y0002299

Nebivolol Hydrochloride

CAS: 152520-56-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Forma y color: White Off-White Powder

Peso molecular: 441.15184

Ref: 45-1457833

Nebivolol hydrochloride

CAS: 152520-56-4

Nebivolol hydrochloride is a beta-1 blocker and vasodilator treating hypertension and heart failure in the elderly.

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: 99.77% - >99.99%

Forma y color: White Solid

Peso molecular: 441.90

Ref: TM-T0154

Nebivolol Hydrochloride

CAS: 152520-56-4

Nebivolol Hydrochloride

Fórmula: C₂₂H₂₆ClF₂NO₄

Pureza: 98%

Peso molecular: 441.9

Ref: 54-PC108965

Nebivolol Hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₆ClF₂NO₄

Pureza: 97%

Forma y color: Solid

Peso molecular: 441.8959

Ref: IN-DA007YL0

Nebivolol hydrochloride

CAS: 152520-56-4

Nebivolol hydrochloride

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: ≥98%, 10 mM in DMSO

Peso molecular: 441.9

Ref: 54-BUP15662

Nebivolol hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: ≥ 98.0% (anhydrous basis)

Forma y color: White to off-white crystalline powder

Peso molecular: 441.90

Ref: 7W-GP6004

Nebivolol HCl

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Forma y color: White To Off-White Solid

Peso molecular: 405.45 36.46

Ref: 4Z-N-201

Nebivolol Hydrochloride

Producto controlado

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·ClH

Forma y color: Neat

Peso molecular: 441.90

Ref: 86-MM0947.00

Nebivolol hydrochloride (Standard)

CAS: 152520-56-4

Nebivolol hydrochloride (Standard) is the standard substance of Nebivolol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Peso molecular: 441.90

Ref: TM-TMSM-1712

Nebivolol Hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄HCl

Peso molecular: 405.4 : 36.46

Ref: ST-EA-CP-N5020

Nebivolol Hydrochloride

CAS: 152520-56-4

Applications Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.
References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990);

Fórmula: C₂₂H₂₅F₂NO₄·ClH

Forma y color: Neat

Peso molecular: 441.9

Ref: TR-N387935

Nebivolol hydrochloride

Producto controlado

CAS: 152520-56-4

Nebivolol HCl is a beta-blocker that is used to treat high blood pressure and heart failure. It is a prodrug that is metabolized in vivo to its active form, nebivolol. Nebivolol HCl has a low bioavailability of about 5%, which may be due to the presence of excipients or the formation of solid dispersions with other ingredients in the formulation. Nebivolol HCl also interacts with many drugs that are metabolized by CYP2D6, CYP3A4, and CYP1A2 enzymes, such as metoprolol succinate, sodium citrate, and hydrochloric acid. This drug also has an adverse effect on geriatric patients because it can cause dizziness due to orthostatic hypotension.

Fórmula: C₂₂H₂₅F₂NO₄•HCl

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 441.9 g/mol

Ref: 3D-FN36779

Nebivolol HCl - Bio-X ™

Producto controlado

CAS: 152520-56-4

Nebivolol is a beta-blocker that is used to treat high blood pressure. It is also used in the treatment of angina, to decrease the heart rate and contractile force. Nebivolol has weak beta-2 adrenergic receptor antagonist action but is a highly selective beta-1 adrenergic receptor antagonist. Nebivolol's ability to block beta-1 adrenergic receptors results in a reduction in myocardial contractility, systolic and diastolic blood pressure, resting heart rate, and workout heart rate.

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: (%) Min. 95%

Forma y color: White/Off-White Solid

Peso molecular: 441.9 g/mol

Ref: 3D-BN164638

Nebivolol Hydrochloride

CAS: 118457-14-0, 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 441.90

Ref: 3B-N0954

Nebivolol hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·ClH

Forma y color: Neat

Peso molecular: 441.90

Ref: 04-C15499900